{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:43:26Z","timestamp":1790660606753,"version":"4.1.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Cerebral small vessel disease is associated with higher ratios of soluble\u2010epoxide hydrolase derived linoleic acid diols (12,13\u2010dihydroxyoctadecenoic acid [DiHOME]\u00a0and 9,10\u2010DiHOME) to their parent epoxides (12(13)\u2010epoxyoctadecenoic acid [EpOME]\u00a0and 9(10)\u2010EpOME); however, the relationship has not yet been examined in stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Participants with mild to moderate small vessel stroke or large vessel stroke were selected based on clinical and imaging\u00a0criteria. Metabolites were quantified by ultra\u2010high\u2010performance liquid chromatography\u2013mass spectrometry. Volumes of stroke, lacunes, white matter hyperintensities, magnetic resonance imaging visible perivascular spaces, and free water diffusion were quantified from structural and diffusion magnetic resonance imaging (3 Tesla). Adjusted linear regression models were used for analysis. Compared with\u00a0participants with large vessel stroke (n=30), participants with small vessel stroke (n=50) had a higher 12,13\u2010DiHOME\/12(13)\u2010EpOME ratio (\u03b2=0.251,\n              <jats:italic>P<\/jats:italic>\n              =0.023). The 12,13\u2010DiHOME\/12(13)\u2010EpOME ratio was associated with more lacunes (\u03b2=0.266,\n              <jats:italic>P<\/jats:italic>\n              =0.028) but not with large vessel stroke volumes. Ratios of 12,13\u2010DiHOME\/12(13)\u2010EpOME and 9,10\u2010DiHOME\/9(10)\u2010EpOME were associated with greater volumes of white matter hyperintensities (\u03b2=0.364,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; \u03b2=0.362,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and white matter MRI\u2010visible perivascular spaces (\u03b2=0.302,\n              <jats:italic>P<\/jats:italic>\n              =0.011; \u03b2=0.314,\n              <jats:italic>P<\/jats:italic>\n              =0.006). In small vessel stroke, the 12,13\u2010DiHOME\/12(13)\u2010EpOME ratio was associated with higher white matter free water diffusion (\u03b2=0.439,\n              <jats:italic>P<\/jats:italic>\n              =0.016), which was specific to the temporal lobe in exploratory regional analyses. The 9,10\u2010DiHOME\/9(10)\u2010EpOME ratio was associated with temporal lobe atrophy (\u03b2=\u22120.277,\n              <jats:italic>P<\/jats:italic>\n              =0.031).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Linoleic acid markers of cytochrome P450\/soluble\u2010epoxide hydrolase activity were associated with small versus large vessel stroke, with small vessel disease markers consistent with blood brain barrier and neurovascular\u2010glial disruption, and temporal lobe atrophy. The findings may indicate a novel modifiable risk factor for small vessel disease and related neurodegeneration.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.026901","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T10:39:12Z","timestamp":1672396752000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5040-6215","authenticated-orcid":false,"given":"Di","family":"Yu","sequence":"first","affiliation":[{"name":"Dr. Sandra Black Center for Brain Resilience &amp; Recovery, LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute Toronto Canada"},{"name":"Department of Pharmacology and Toxicology University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6802-5015","authenticated-orcid":false,"given":"Nuanyi","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology University of California Davis CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5214-4503","authenticated-orcid":false,"given":"Julia","family":"Zebarth","sequence":"additional","affiliation":[{"name":"Dr. Sandra Black Center for Brain Resilience &amp; Recovery, LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute Toronto Canada"},{"name":"Department of Pharmacology and Toxicology University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6825-2234","authenticated-orcid":false,"given":"Qing","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology University of California Davis CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miracle","family":"Ozzoude","sequence":"additional","affiliation":[{"name":"Dr. Sandra Black Center for Brain Resilience &amp; Recovery, LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5880-0818","authenticated-orcid":false,"given":"Maged","family":"Goubran","sequence":"additional","affiliation":[{"name":"Dr. Sandra Black Center for Brain Resilience &amp; Recovery, LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute Toronto Canada"},{"name":"Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre Toronto Canada"},{"name":"Department of Medical Biophysics University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4754-2221","authenticated-orcid":false,"given":"Jennifer S.","family":"Rabin","sequence":"additional","affiliation":[{"name":"Dr. Sandra Black Center for Brain Resilience &amp; Recovery, LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute Toronto Canada"},{"name":"Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre Toronto Canada"},{"name":"Division of Neurology, Department of Medicine Sunnybrook Health Sciences Centre Toronto Canada"},{"name":"Rehabilitation Sciences Institute University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5582-1776","authenticated-orcid":false,"given":"Joel","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Dr. Sandra Black Center for Brain Resilience &amp; Recovery, LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3236-7523","authenticated-orcid":false,"given":"Christopher J. 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