{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:28:32Z","timestamp":1792596512676,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,4,18]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Aortic aneurysm rupture and acute aortic dissection are life\u2010threatening conditions and represent an ever\u2010growing public health challenge. Comprehensive epidemiologic investigations for their risk factors are scant. We aimed to investigate risk factors associated with mortality from aortic diseases through analysis of a community\u2010based Japanese cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">IPHS (Ibaraki Prefectural Health Study) comprises 95\u2009723 participants who took part in municipal health checkups in 1993. Factors considered for analysis included age, sex, body mass index, blood pressure, serum lipids (high\u2010density lipoprotein [HDL] cholesterol, non\u2010HDL cholesterol, and triglycerides), diabetes, antihypertensive and lipid\u2010lowering drug use, and smoking and drinking habits. Cox proportional hazards models were applied to evaluate the associations between these variables and mortality from aortic diseases. During the median 26\u2010year follow\u2010up, 190 participants died of aortic aneurysm rupture, and 188 died of aortic dissection. An increased multivariable hazard ratio (HR) for mortality from total aortic diseases was observed for high systolic blood pressure (1.61 [1.00\u20132.59]), diastolic blood pressure (2.95 [1.95\u20134.48]), high non\u2010HDL cholesterol (1.63 [1.19\u20132.24]), low HDL cholesterol (1.86 [1.29\u20132.68]), and heavy (&gt;20 cigarettes\/day) smoking habit (2.46 [1.66\u20133.63]). A lower multivariable HR was observed for diabetes (0.50 [0.28\u20130.89]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Smoking habit, higher systolic blood pressure and diastolic blood pressure levels, higher non\u2010HDL, and lower HDL cholesterol levels were positively associated with mortality from total aortic diseases, whereas diabetes was inversely associated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.122.027045","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T05:10:34Z","timestamp":1681276234000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Risk Factors for Mortality From Aortic Aneurysm and Dissection: Results From a 26\u2010Year Follow\u2010Up of a Community\u2010Based Population"],"prefix":"10.1161","volume":"12","author":[{"given":"Ai","family":"Koba","sequence":"first","affiliation":[{"name":"Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center University of Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3301-5519","authenticated-orcid":false,"given":"Kazumasa","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center University of Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8896-6501","authenticated-orcid":false,"given":"Toshimi","family":"Sairenchi","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center University of Tsukuba Japan"},{"name":"Department of Public Health Dokkyo Medical University Mibu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9086-3771","authenticated-orcid":false,"given":"Hiroyuki","family":"Noda","sequence":"additional","affiliation":[{"name":"Public Health, Department of Social Medicine Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5318-7233","authenticated-orcid":false,"given":"Fujiko","family":"Irie","sequence":"additional","affiliation":[{"name":"Department of Health and Welfare Ibaraki Prefectural Office Mito Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobue","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Health and Welfare Ibaraki Prefectural Office Mito Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6667-9306","authenticated-orcid":false,"given":"Takuji","family":"Tomizawa","sequence":"additional","affiliation":[{"name":"Ibaraki Health Service Association Mito Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9241-7289","authenticated-orcid":false,"given":"Hiroyasu","family":"Iso","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center University of Tsukuba Japan"},{"name":"Public Health, Department of Social Medicine Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Ota","sequence":"additional","affiliation":[{"name":"Ibaraki Health Plaza Mito Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(14)61005-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66459-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8698"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jja2.12013"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.02.028"},{"key":"e_1_3_2_7_2","unstructured":"Ministry of Health Labour and Welfare . Table 7. Number of deaths and mortality rates by sex and by simple cause of death (per 100 0000 polulation). [in Japanese]. Summary of Vital Statistics 2017. Published 2018. Accessed 1 April 2023. https:\/\/www.mhlw.go.jp\/toukei\/saikin\/hw\/jinkou\/kakutei17\/dl\/11_h7.pdf."},{"key":"e_1_3_2_8_2","first-page":"1","article-title":"Epidemiology and trend of aortic diseases in Japan","volume":"55","author":"Kihara T","year":"2020","unstructured":"Kihara T, Yamagishi K, Takada IH. Epidemiology and trend of aortic diseases in Japan. Article in Japanese.\u00a0Jpn Soc Cardiovasc Dis Prev. 2020;55:1\u20135.","journal-title":"Jpn Soc Cardiovasc Dis Prev."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.05.090"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.12.007"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/sjos.12167"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15122805"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2016.08.044"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32100-2"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.06.022"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300158"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000199268.27395.4f"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031264"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-18-0721"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01225-8"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-019-00510-9"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60685-1"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-019-1466-4"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450119666180122155642"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11168"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004725"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.3.1580"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1382288"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1556075"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy174"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/1479164116651389"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arteri.2018.01.002"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/1479164118780799"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.027045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:50:44Z","timestamp":1715590244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.027045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,18]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,4,18]]}},"alternative-id":["10.1161\/JAHA.122.027045"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.027045","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,18]]},"assertion":[{"value":"2022-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e027045"}}