{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:03:36Z","timestamp":1793117016197,"version":"4.5.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,2,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Heart transplantation with a donation after circulatory death (DCD) heart is complicated by substantial organ ischemia and ischemia\u2013reperfusion injury. Exenatide, a glucagon\u2010like peptide\u22121 receptor agonist, manifests protection against cardiac ischemia\u2013reperfusion injury in other settings. Here we evaluate the effects of exenatide on DCD hearts in juvenile pigs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              DCD hearts with 15\u2010minutes of global warm ischemia after circulatory arrest were reperfused ex vivo and switched to working mode. Treatment with concentration 5\u2010nmol exenatide was given during reperfusion. DCD hearts treated with exenatide showed higher myocardial oxygen consumption (exenatide [n=7] versus controls [n=7], over 60\u2013120\u2009minutes of reperfusion,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and lower cardiac troponin\u2010I release (27.94\u00b111.17 versus 42.25\u00b111.80\u2009mmol\/L,\n              <jats:italic>P<\/jats:italic>\n              =0.04) during reperfusion compared with controls. In working mode, exenatide\u2010treated hearts showed better diastolic function (dp\/dt min: \u22123644\u00b1620 versus \u22122193\u00b1610\u2009mm\u2009Hg\/s,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; Tau: 15.62\u00b11.78 versus 24.59\u00b17.35\u2009milliseconds,\n              <jats:italic>P<\/jats:italic>\n              =0.02; lateral\n              <jats:italic>e<\/jats:italic>\n              \u2032 velocity: 11.27\u00a0\u00b1\u20091.46 versus 7.19\u00b12.96,\n              <jats:italic>P<\/jats:italic>\n              =0.01), as well as lower venous lactate levels (3.17\u00b10.75 versus 5.17\u00b11.44\u2009mmol\/L,\n              <jats:italic>P<\/jats:italic>\n              =0.01) compared with controls. Higher levels of activated endothelial nitric oxide synthase (phosphorylated to total endothelial nitric oxide synthase levels: 2.71\u00b11.16 versus 1.37\u00b10.35,\n              <jats:italic>P<\/jats:italic>\n              =0.02) with less histological evidence of endothelial damage (von Willebrand factor expression: 0.024\u00b10.007 versus 0.331\u00b10.302, pixel\/\u03bcm,\n              <jats:italic>P<\/jats:italic>\n              =0.04) was also observed with exenatide treatment versus controls.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Acute treatment of DCD hearts with exenatide limits myocardial and endothelial injury and improves donor cardiac function.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027163","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T10:55:57Z","timestamp":1674644157000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Cardioprotective Actions of a Glucagon\u2010like Peptide\u20101 Receptor Agonist on Hearts Donated After Circulatory Death"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5563-7450","authenticated-orcid":false,"given":"Sachiko","family":"Kadowaki","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Surgery The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Surgery University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-7261","authenticated-orcid":false,"given":"M. Ahsan","family":"Siraj","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ted Rogers Centre for Heart Research, Peter Munk Cardiac Centre University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiden","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Surgery University of Toronto Toronto Ontario Canada"},{"name":"Department of Cardiac Surgery Guangzhou Women and Children\u2019s Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Perfusion Services The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlee","family":"Parker","sequence":"additional","affiliation":[{"name":"Division of Perfusion Services The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2904-0618","authenticated-orcid":false,"given":"Anita","family":"Nagy","sequence":"additional","affiliation":[{"name":"Division of Pathology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-0118","authenticated-orcid":false,"given":"Chun\u2010Po","family":"Steve Fan","sequence":"additional","affiliation":[{"name":"Ted Rogers Centre for Heart Research, Peter Munk Cardiac Centre, Labatt Family Heart Centre University Health Network, The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6750-4700","authenticated-orcid":false,"given":"Kyle","family":"Runeckles","sequence":"additional","affiliation":[{"name":"Ted Rogers Centre for Heart Research, Peter Munk Cardiac Centre, Labatt Family Heart Centre University Health Network, The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Surgery University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3911-4067","authenticated-orcid":false,"given":"Junko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Surgery University of Toronto Toronto Ontario Canada"},{"name":"Department of Cardiovascular Surgery Okayama University Hospital Okayama Japan"},{"name":"Department of Cardiovascular Surgery Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Haller","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Surgery University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3740-6739","authenticated-orcid":false,"given":"Mansoor","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ted Rogers Centre for Heart Research, Peter Munk Cardiac Centre University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6373-0532","authenticated-orcid":false,"given":"Osami","family":"Honjo","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery The Hospital for Sick 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