{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:23:00Z","timestamp":1790630580160,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,10,4]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Several longitudinal studies have reported that higher visit\u2010to\u2010visit blood pressure variability is associated with greater risk for developing chronic kidney disease. However, no population\u2010based studies have investigated the association between day\u2010to\u2010day home blood pressure variability and incident chronic kidney disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 2342 Japanese community\u2010dwelling residents aged \u226540\u2009years without chronic kidney disease at baseline were followed up by annual health examinations for 10\u2009years. Home blood pressure was measured 3 times every morning for 28\u2009days. Day\u2010to\u2010day coefficients of variation of home systolic blood pressure levels were categorized into quintiles. Chronic kidney disease was defined as an estimated glomerular filtration rate\u00a0&lt;60\u2009mL\/min per 1.73\u2009m\n              <jats:sup>2<\/jats:sup>\n              or the presence of proteinuria. The hazard ratios for developing chronic kidney disease were estimated with a Cox proportional hazards model. During the follow\u2010up period, 772 participants developed chronic kidney disease. Increased coefficients of variation of home systolic blood pressure were associated significantly with higher risk of chronic kidney disease after adjusting for confounders (\n              <jats:italic>P<\/jats:italic>\n              for trend &lt;0.001): Individuals in the highest quintile of coefficients of variation had a 1.50\u2010fold (95% CI, 1.17\u20131.94) greater risk of developing chronic kidney disease than those in the lowest quintile. The combination of higher coefficients of variation and higher mean value of home systolic blood pressure was associated with the multivariable\u2010adjusted risk of developing chronic kidney disease.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">These findings suggest that increased day\u2010to\u2010day blood pressure variability is a significant risk factor for developing chronic kidney disease in a general Japanese population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027173","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T09:42:08Z","timestamp":1664444528000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Day\u2010to\u2010Day Blood Pressure Variability and Risk of Incident Chronic Kidney Disease in a General Japanese Population"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9525-2638","authenticated-orcid":false,"given":"Takaya","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"},{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6750-5762","authenticated-orcid":false,"given":"Satoko","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"},{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"},{"name":"Center for Cohort Studies, Graduate School of Medical Sciences Kyushu 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