{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:26:25Z","timestamp":1774945585485,"version":"3.50.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,2,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Information about the cardiac manifestations of the Omicron variant of COVID\u201019 is limited. We performed a systematic prospective echocardiographic evaluation of consecutive patients hospitalized with the Omicron variant of COVID\u201019 infection and compared them with similarly recruited patients were propensity matched with the wild\u2010type variant.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 162 consecutive patients hospitalized with Omicron COVID\u201019 underwent complete echocardiographic evaluation within 24\u2009hours of admission and were compared with propensity\u2010matched patients with the wild\u2010type variant (148 pairs). Echocardiography included left ventricular (LV) systolic and diastolic, right ventricular (RV), strain, and hemodynamic assessment. Echocardiographic parameters during acute infection were compared with historic exams in 62 patients with the Omicron variant and 19 patients with the wild\u2010type variant who had a previous exam within 1 year. Of the patients, 85 (53%) had a normal echocardiogram. The most common cardiac pathology was RV dilatation and dysfunction (33%), followed by elevated LV filling pressure (E\/e\u2032 \u226514, 29%) and LV systolic dysfunction (ejection fraction &lt;50%, 10%). Compared with the matched wild\u2010type cohort, patients with Omicron had smaller RV end\u2010systolic areas (9.3\u00b14 versus 12.3\u00b14\u2009cm\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.0003), improved RV function (RV fractional\u2010area change, 53.2%\u00b110% versus 39.7%\u00b113% [\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001]; RV S\u2032, 12.0\u00b13 versus 10.7\u00b13\u2009cm\/s [\n              <jats:italic>P<\/jats:italic>\n              =0.001]), and higher stroke volume index (35.6 versus 32.5\u2009mL\/m\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.004), all possibly related to lower mean pulmonary pressure (34.6\u00b112 versus 41.1\u00b114\u2009mm\u2009Hg;\n              <jats:italic>P<\/jats:italic>\n              =0.0001) and the pulmonary vascular resistance index (\n              <jats:italic>P<\/jats:italic>\n              =0.0003). LV systolic or diastolic parameters were mostly similar to the wild\u2010type variant\u2010matched cohort apart from larger LV size. However, in patients who had a previous echocardiographic exam, these LV abnormalities were recorded before acute Omicron infection, but not in the wild\u2010type cohort. Numerous echocardiographic parameters were associated with higher in\u2010hospital mortality (LV ejection fraction, stroke volume index, E\/e\u2032, RV S\u2032).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with Omicron, RV function is impaired to a lower extent compared with the wild\u2010type variant, possibly related to the attenuated pulmonary parenchymal and\/or vascular disease. LV systolic and diastolic abnormalities are as common as in the wild\u2010type variant but were usually recorded before acute infection and probably reflect background cardiac morbidity. Numerous LV and RV abnormalities are associated with adverse outcome in patients with Omicron.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027188","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T10:50:32Z","timestamp":1674643832000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Cardiologic Manifestations in Omicron\u2010Type Versus Wild\u2010Type COVID\u201019: A Systematic Echocardiographic Study"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5029-0232","authenticated-orcid":false,"given":"Eihab","family":"Ghantous","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2120-0306","authenticated-orcid":false,"given":"Aviel","family":"Shetrit","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9404-3145","authenticated-orcid":false,"given":"Aviram","family":"Hochstadt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3464-3341","authenticated-orcid":false,"given":"Ariel","family":"Banai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lior","family":"Lupu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erez","family":"Levi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1398-3563","authenticated-orcid":false,"given":"Yishay","family":"Szekely","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7391-2487","authenticated-orcid":false,"given":"Nadav","family":"Schellekes","sequence":"additional","affiliation":[{"name":"Tel Aviv Sourasky Medical Center and Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy","family":"Jacoby","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Zahler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine Tel Aviv University Tel Aviv 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Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7537-6078","authenticated-orcid":false,"given":"Dana","family":"Viskin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6021-8915","authenticated-orcid":false,"given":"Lia","family":"Shidlansik","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2957-9741","authenticated-orcid":false,"given":"Amos","family":"Adler","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory, Tel Aviv Sourasky 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