{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:32:12Z","timestamp":1753889532508,"version":"3.41.2"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,2,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Cerebral microbleeds (CMBs) are increasingly recognized as \u201ccovert\u201d brain lesions indicating increased risk of future neurological events. However, data on CMBs in patients undergoing catheter\u2010based structural heart interventions are scarce. Therefore, we assessed occurrence and predictors of new CMBs in patients undergoing catheter\u2010based left atrial appendage closure and percutaneous mitral valve repair using the MitraClip System.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We conducted an exploratory analysis using data derived from 2 prospective, observational studies. Eligible patients underwent cerebral magnetic resonance imaging (3\u2009Tesla) examinations and cognitive tests (using the Montreal Cognitive Assessment) before and after catheter\u2010based left atrial appendage closure and percutaneous mitral valve repair. Forty\u2010seven patients (53% men; median age, 77\u2009years) were included. New CMBs occurred in 17 of 47 patients (36%) following catheter\u2010based structural heart interventions. Occurrences of new CMBs did not differ significantly between patients undergoing catheter\u2010based left atrial appendage closure and percutaneous mitral valve repair (7\/25 versus 10\/22;\n              <jats:italic>P<\/jats:italic>\n              =0.348). In univariable analysis, longer procedure time was significantly associated with new CMBs. Adjustment for heparin attenuated this association (adjusted odds ratio [per 30\u2009minutes]: 1.77 [95% CI, 0.92\u20133.83];\n              <jats:italic>P<\/jats:italic>\n              =0.090).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">New CMBs occur in approximately one\u2010third of patients after catheter\u2010based left atrial appendage closure and percutaneous mitral valve repair using the MitraClip System. Our data suggest that longer duration of the procedure may be a risk factor for new CMBs. Future studies in larger populations are needed to further investigate their clinical relevance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              German Clinical Trials Register: DRKS00010300 (\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/drks.de\/search\/en\/trial\/DRKS00010300\">https:\/\/drks.de\/search\/en\/trial\/DRKS00010300<\/jats:ext-link>\n              );\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n              : NCT03104556 (\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03104556?term=NCT03104556%26draw=2%26rank=1\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03104556?term=NCT03104556&amp;draw=2&amp;rank=1<\/jats:ext-link>\n              ).\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027284","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T11:30:15Z","timestamp":1675423815000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["New Cerebral Microbleeds After Catheter\u2010Based Structural Heart Interventions: An Exploratory Analysis"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6112-2800","authenticated-orcid":false,"given":"Tim Bastian","family":"Braemswig","sequence":"first","affiliation":[{"name":"Klinik und Hochschulambulanz f\u00fcr Neurologie Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin Berlin Germany"},{"name":"Berlin Institute of Health (BIH) at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"},{"name":"Center for Stroke Research Berlin (CSB) Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin Berlin Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), partner site Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine","family":"Kusserow","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin Bundeswehrkrankenhaus Berlin Berlin Germany"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-9376","authenticated-orcid":false,"given":"Barbara","family":"Bellmann","sequence":"additional","affiliation":[{"name":"MEDIAN Klinik AGZ D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"Department of Cardiology Campus Benjamin Franklin Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-4366","authenticated-orcid":false,"given":"Frederik","family":"Beckhoff","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campus Benjamin Franklin Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Reinthaler","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campus Benjamin Franklin Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin Berlin Germany"},{"name":"Institute of Active Polymers and Berlin\u2010Brandenburg Center for Regenerative Therapies Helmholtz\u2010Zentrum Hereon Teltow Germany"},{"name":"Deutsches Herzzentrum der Charit\u00e9, Klinik f\u00fcr Kardiologie Angiologie und Intensivmedizin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3444-2045","authenticated-orcid":false,"given":"Regina","family":"von Rennenberg","sequence":"additional","affiliation":[{"name":"Klinik und Hochschulambulanz f\u00fcr Neurologie Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie 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