{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:08:11Z","timestamp":1791461291562,"version":"4.3.4"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,2,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Sleep irregularity has been linked to incident cardiovascular disease. Less is known about associations of sleep regularity with atherosclerosis. We examined cross\u2010sectional associations of actigraphy\u2010assessed sleep duration and sleep timing regularity with subclinical atherosclerosis in the community\u2010based MESA (Multi\u2010Ethnic Study of Atherosclerosis).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">MESA Sleep Ancillary Study participants (N=2032; mean age, 68.6\u00b19.2\u2009years; 37.9% White) completed 7\u2010day wrist actigraphy. Participants underwent assessments of coronary artery calcium, carotid plaque presence, carotid intima\u2010media thickness, and the ankle\u2010brachial index. Sleep regularity was quantified by the 7\u2010day with\u2010in person SD of sleep duration and sleep onset timing. Relative risk regression models were used to calculate prevalence ratios and 95% CIs. Models are adjusted for demographics, cardiovascular disease risk factors, and other objectively assessed sleep characteristics including obstructive sleep apnea, sleep duration, and sleep fragmentation. After adjustment, compared with participants with more regular sleep durations (SD \u226460\u2009minutes), participants with greater sleep duration irregularity (SD &gt;120\u2009minutes) were more likely to have high coronary artery calcium burden (&gt;300; prevalence ratio, 1.33 [95% CI, 1.03\u20131.71]) and abnormal ankle\u2010brachial index (&lt;0.9; prevalence ratio, 1.75 [95% CI, 1.03\u20132.95]). Compared with participants with more regular sleep timing (SD \u226430\u2009minutes), participants with irregular sleep timing (SD &gt;90\u2009minutes) were more likely to have high coronary artery calcium burden (prevalence ratio, 1.39 [95% CI, 1.07\u20131.82]). Associations persisted after adjustment for cardiovascular disease risk factors and average sleep duration, obstructive sleep apnea, and sleep fragmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Sleep irregularity, particularly sleep duration irregularity, was associated with several measures of subclinical atherosclerosis. Sleep regularity may be a modifiable target for reducing atherosclerosis risk. Future investigation into cardiovascular risk reduction interventions targeting sleep irregularity may be warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.122.027361","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T07:16:51Z","timestamp":1676963811000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":91,"title":["Sleep Irregularity and Subclinical Markers of Cardiovascular Disease: The Multi\u2010Ethnic Study of Atherosclerosis"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-0228","authenticated-orcid":false,"given":"Kelsie M.","family":"Full","sequence":"first","affiliation":[{"name":"Division of Epidemiology and Community Health University of Minnesota School of Public Health Minneapolis 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