{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:49:34Z","timestamp":1790120974952,"version":"4.0.1"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,4,4]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Abnormal regulation of vascular smooth muscle cells is regarded as the iconic pathological change of aortic dissection (AD). Herein, we aim to identify\n              <jats:italic>circ_0022920<\/jats:italic>\n              as a crucial regulator in AD.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Microarray analysis of circular RNAs, messenger RNAs, and micro RNAs in patients with AD was performed, and we identified that\n              <jats:italic>circ_0022920<\/jats:italic>\n              was significantly downregulated in these patients. The Pearson correlation analysis uncovered the negative correlation between\n              <jats:italic>miR\u2010650<\/jats:italic>\n              and\n              <jats:italic>circ_0022920<\/jats:italic>\n              or TGF\u03b2R1 (transforming growth factor beta receptor 1). Angiotensin II was used to treat human aortic vascular smooth muscle cells (HASMCs) and mice as models for AD. Hematoxylin and eosin and Masson's trichrome staining were used to analyze AD histopathology. Cell proliferation was analyzed with Cell Counting Kit\u20108 assay and EdU incorporation. Cell migration was assessed with transwell and wound healing assays. Enhanced\n              <jats:italic>circ_0022920<\/jats:italic>\n              expression dramatically inhibited HASMC proliferation and migration and maintained contractile marker expression induced by angiotensin II, whereas\n              <jats:italic>miR\u2010650<\/jats:italic>\n              exerted opposite effects.\n              <jats:italic>MiR\u2010650<\/jats:italic>\n              was a target of\n              <jats:italic>circ_0022920<\/jats:italic>\n              .\n              <jats:italic>MiR\u2010650<\/jats:italic>\n              targeted IRF1 (interferon regulatory factor 1) and thus negatively regulated TGF\u03b2R1 expression to promote HASMC proliferation and migration and inhibit contractile marker expression.\n              <jats:italic>Circ_0022920<\/jats:italic>\n              suppressed the progression of AD in vivo.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:italic>Circ_0022920<\/jats:italic>\n              modulates the contractile phenotype of HASMCs via regulating the\n              <jats:italic>miR\u2010650<\/jats:italic>\n              \u2010IRF1\u2010TGF\u03b2R1 axis in angiotensin II\u2010induced models for AD, which provides potential therapeutic targets for AD.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027425","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T09:22:36Z","timestamp":1679995356000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["<i>Circ_0022920<\/i>\n            Maintains the Contractile Phenotype of Human Aortic Vascular Smooth Muscle Cells Via Sponging\n            <i>microRNA\u2010650<\/i>\n            and Promoting Transforming Growth Factor Beta Receptor 1 Expression in Angiotensin II\u2010Induced Models for Aortic Dissection"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3858-6046","authenticated-orcid":false,"given":"Mao\u2010Xun","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Second Hospital of Jilin University, Jilin University Changchun Jilin Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu\u2010Lin","family":"Piao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Second Hospital of Jilin University, Jilin University Changchun Jilin Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Second Hospital of Jilin University, Jilin University Changchun Jilin Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Cheng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Second Hospital of Jilin University, Jilin University Changchun Jilin Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ri\u2010Hao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Second Hospital of Jilin University, Jilin University Changchun Jilin Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010Ce","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Second Hospital of Jilin University, Jilin University Changchun Jilin Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Second Hospital of Jilin University, Jilin University Changchun Jilin Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9350-4499","authenticated-orcid":false,"given":"Ke\u2010Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Second Hospital of Jilin University, Jilin University Changchun Jilin Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.71"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.799908"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)65594-4"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.1.311"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000130644.78677.2C"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2015.12.003"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055695"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-305130"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307130"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy006"},{"issue":"1","key":"e_1_3_1_12_2","first-page":"II329","article-title":"Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm","volume":"108","author":"Nataatmadja M","year":"2003","unstructured":"Nataatmadja M, West M, West J, Summers K, Walker P, Nagata M, Watanabe T. Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm. Circulation. 2003;108(Suppl 1):II329\u2013II334.","journal-title":"Circulation"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03085963"},{"key":"e_1_3_1_14_2","first-page":"2764","article-title":"TGF\u2010beta1 induces human aortic vascular smooth muscle cell phenotype switch through PI3K\/AKT\/ID2 signaling","volume":"7","author":"Zhu SB","year":"2015","unstructured":"Zhu SB, Zhu J, Zhou ZZ, Xi EP, Wang RP, Zhang Y. TGF\u2010beta1 induces human aortic vascular smooth muscle cell phenotype switch through PI3K\/AKT\/ID2 signaling. Am J Transl Res. 2015;7:2764\u20132774.","journal-title":"Am J Transl Res"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2015.00002"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3074"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030733"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003777"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.035667.112"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11928"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-1426-1_20"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0962-1"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.29750"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27384"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2016-103758"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18998"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1040-0"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep28149"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep35444"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.1080"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144916"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.08.025"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq230"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.05.084"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.02.021"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2015.00125"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.11.113"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13104-w"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2019.60.4.352"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9308"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1159\/000488834"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190156"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219013"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1159\/000495495"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17743"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.310371"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19072125"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1116"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124287"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38136"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004968"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.027425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:51:40Z","timestamp":1715604700000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.027425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,4]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,4,4]]}},"alternative-id":["10.1161\/JAHA.122.027425"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.027425","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,4]]},"assertion":[{"value":"2022-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e027425"}}