{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:20:09Z","timestamp":1789759209928,"version":"4.0.1"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,12,20]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The patterns of depressive symptom change during the first month after discharge, as well as their prognostic implications, and predictors of persistent or new\u2010onset depressive symptoms are not well characterized.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We included patients hospitalized for heart failure undergoing Patient Health Questionnaire\u20102 before discharge and at 1\u2009month after discharge in a multicenter prospective cohort. We characterized 4 patterns of change in depressive symptoms\u2014persistent, new\u2010onset, remitted depressive symptoms, and no depressive symptom\u2014and examined the associations between the 4 patterns and 1\u2010year clinical outcomes. We analyzed the factors associated with persistent or new\u2010onset depressive symptoms. A total of 4130 patients were included. Among 1175 (28.5%) symptomatic patients and 2955 (71.5%) symptom\u2010free patients before discharge, 817 (69.5%) had remission, and 366 (12.2%) had new\u2010onset depressive symptoms, respectively. Compared with no depressive symptom, persistent depressive symptoms were associated with an increased risk of cardiovascular death (hazard ratio [HR], 2.10 [95% CI, 1.59\u20132.79]) and heart failure rehospitalization (HR, 1.56 [95% CI, 1.30\u20131.87]); new\u2010onset depressive symptoms were associated with an increased risk of cardiovascular death (HR, 1.78 [95%CI, 1.32\u20132.40]) and heart failure rehospitalization (HR, 1.54 [95% CI, 1.29\u20131.83]). Remitted depressive symptoms were associated with a slightly increased risk of cardiovascular death but had no significant association with heart failure rehospitalization. Patients who were female or had poor socioeconomic status, stroke history, renal dysfunction, or poor health status had a higher risk of persistent or new\u2010onset depressive symptoms.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Sex, socioeconomic status, clinical characteristics, and health status help identify patients with high risks of depressive symptoms at 1\u2009month after discharge. Dynamic capture of depressive symptom change during this period informs long\u2010term risk stratifications and targets patients who require psychological interventions and social support to improve clinical outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier (NCT02878811).\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027438","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T11:38:45Z","timestamp":1671017925000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Change in Depressive Symptoms During the First Month of Discharge and 1\u2010Year Clinical Outcomes in Patients Hospitalized for Heart Failure"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5386-4975","authenticated-orcid":false,"given":"Bin","family":"Wang","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing People\u2019s Republic of China"},{"name":"Fuwai Hospital, Chinese Academy of Medical Sciences Shenzhen People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubi","family":"Lei","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of 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