{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T23:29:09Z","timestamp":1794266949666,"version":"4.9.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,12,6]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">We investigated the longitudinal association of herpes zoster (HZ), commonly known as \u201cshingles,\u201d and long\u2010term risk of stroke or coronary heart disease (CHD) among participants in 3 large US cohorts, the NHS (Nurses' Health Study), NHS II (Nurses' Health Study II), and HPFS (Health Professionals Follow\u2010Up Study).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Participants were 79\u2009658 women in the NHS (2000\u20132016), 93\u2009932 women in the NHS II (2001\u20132017), and 31\u2009440 men in the HPFS (2004\u20132016), without prior stroke or CHD. Information on HZ, stroke, and CHD was collected on biennial questionnaires and confirmed by medical record review. Cox proportional hazards regression models were used to estimate multivariable\u2010adjusted hazard ratios for stroke and for CHD according to years since HZ compared with never HZ. During &gt;2\u00a0million person\u2010years of follow\u2010up, 3603 incident stroke and 8620 incident CHD cases were documented. History of HZ was significantly and independently associated with higher long\u2010term risk of stroke and CHD. In pooled analyses, compared with individuals with no history of HZ, the multivariable\u2010adjusted hazard ratios (95% CIs) for stroke were 1.05 (0.88\u20131.25) among those with 1 to 4\u2009years since HZ, 1.38 (1.10\u20131.74) for among those with 5 to 8\u2009years since HZ, 1.28 (1.03\u20131.59) among those with for 9 to 12\u2009years since HZ, and 1.19 (0.90\u20131.56) among those with \u226513\u2009years since HZ. For CHD, the corresponding multivariable\u2010adjusted hazard ratios (95% CIs) were 1.13 (1.01\u20131.27) for 1 to 4\u2009years, 1.16 (1.02\u20131.32) for 5 to 8\u2009years, 1.25 (1.07\u20131.46) for 9 to 12\u2009years, and 1.00 (0.83\u20131.21) for \u226513\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">HZ is associated with higher long\u2010term risk of a major cardiovascular event. These findings suggest there are long\u2010term implications of HZ and underscore the importance of prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.122.027451","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T08:32:42Z","timestamp":1668587562000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Herpes Zoster and Long\u2010Term Risk of Cardiovascular Disease"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0282-0822","authenticated-orcid":false,"given":"Sharon G.","family":"Curhan","sequence":"first","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women\u2019s Hospital Boston MA"},{"name":"Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0908-5296","authenticated-orcid":false,"given":"Kosuke","family":"Kawai","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA"},{"name":"Institutional Centers for Clinical and Translational Research Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Yawn","sequence":"additional","affiliation":[{"name":"Department of Research Olmsted Medical Center Rochester MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3387-8429","authenticated-orcid":false,"given":"Kathryn M.","family":"Rexrode","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA"},{"name":"Division of Women\u2019s Health Brigham and Women\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1402-7250","authenticated-orcid":false,"given":"Eric B.","family":"Rimm","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women\u2019s Hospital Boston MA"},{"name":"Harvard Medical School Boston MA"},{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health Boston MA"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-6305","authenticated-orcid":false,"given":"Gary C.","family":"Curhan","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women\u2019s Hospital Boston MA"},{"name":"Harvard Medical School Boston MA"},{"name":"Department of Epidemiology Harvard T.H. 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