{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:23:53Z","timestamp":1793298233657,"version":"4.5.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,3,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Whether sex\u2010specific differences exist for risk factors for pulmonary embolism (PE) and deep venous thrombosis (DVT), with the exception of pregnancy and estrogen therapy, has been sparsely studied. We aimed to study whether sex\u2010specific differences of risk factors exist for noncancer\u2010related DVT and PE in middle\u2010aged and older individuals without cardiovascular history or previous diagnosis in a population\u2010based historical (retrospective) cohort.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Potential venous thromboembolism (VTE) risk factors were registered at baseline in 15\u2009807 women and 9996 men aged 44 to 74\u2009years, who participated in the Malm\u00f6 Diet and Cancer study (1991\u20131996). We excluded subjects with a previous history of VTE, cancer, a diagnosis of cardiovascular disease, or a diagnosis of cancer\u2010associated VTE during follow\u2010up. Patients were followed up from baseline until the first event of PE or DVT, death, or December 31, 2018. During the follow\u2010up period, 365 (2.3%) women and 168 (1.7%) men were affected by first DVT, and 309 (2.0%) women and 154 (1.5%) men were affected by first PE. In the multivariable Cox regression models, the anthropometric obesity markers of weight, body mass index, waist and hip circumference, fat percentage, and muscle weight were in a dose\u2010dependent way associated with DVT and PE among women but not men. In an analysis that included patients with cardiovascular disease and cancer\u2010related VTE, the results were similar for women. For men, several obesity measures became significantly associated with PE or DVT but were weaker than in women, especially for DVT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Anthropometric obesity measures are more important risk factors for both DVT and PE among women than men, especially for individuals without cardiovascular history or previous diagnosis or cancer\u2010related VTE.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027502","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T10:15:30Z","timestamp":1677492930000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Sex\u2010Specific Risk Factors for Deep Venous Thrombosis and Pulmonary Embolism in a Population\u2010Based Historical Cohort Study of Middle\u2010Aged and Older Individuals"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8630-1407","authenticated-orcid":false,"given":"Annie","family":"Brink","sequence":"first","affiliation":[{"name":"Center for Primary Health Care Research Lund University and Region Sk\u00e5ne Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Elf","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2901-6877","authenticated-orcid":false,"given":"Peter J.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8618-9152","authenticated-orcid":false,"given":"Gunnar","family":"Engstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-5613","authenticated-orcid":false,"given":"Bengt","family":"Z\u00f6ller","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University and Region Sk\u00e5ne Malm\u00f6 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