{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:12:47Z","timestamp":1791832367321,"version":"4.3.4"},"reference-count":64,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,7,18]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Indication for prophylactic surgical abdominal aortic aneurysm (AAA) repair depends on the maximal aortic diameter. The lectin\u2010like oxidized low\u2010density lipoprotein receptor\u20101 (LOX\u20101) is the major receptor for uptake of oxidized low\u2010density lipoprotein cholesterol and is implicated in atherosclerosis. A soluble form of LOX\u20101 (sLOX\u20101) has been discussed as a novel biomarker in coronary artery disease and stroke. Herein, we assessed the regulation of aortic LOX\u20101 as well as the diagnostic and risk stratification potential of sLOX\u20101 in patients with AAA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Serum sLOX\u20101 was assessed in a case\u2013control study in AAA (n=104) and peripheral artery disease (n=104). sLOX\u20101 was not statistically different between AAA and peripheral artery disease but was higher in AAA (\u03b2=1.28,\n              <jats:italic>P<\/jats:italic>\n              =0.04) after adjusting for age, atherosclerosis, type 2 diabetes, prescription of statins, \u03b2\u2010blockers, ACE inhibitors, and therapeutic anticoagulation. sLOX\u20101 was not associated with the aortic diameter, AAA volume, or the thickness of the intraluminal thrombus. Aortic LOX\u20101 mRNA expression tended to be higher in AAA when compared with disease, and expression was positively associated with cleaved caspase\u20103, smooth muscle actin, collagen, and macrophage content.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In AAA, sLOX\u20101 was differently affected by age, cardiometabolic diseases, and corresponding medical therapies. Comparison with nonatherosclerotic disease would be beneficial to further elucidate the diagnostic potential of sLOX\u20101, although it was not useful for risk stratification. Aneurysmal LOX\u20101 mRNA expression was increased and positively associated with smooth muscle cells and collagen content, suggesting that LOX\u20101 is eventually not deleterious in human AAA and could counteract AAA rupture.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027537","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T11:23:52Z","timestamp":1688815432000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Associations of Tissue and Soluble LOX\u20101 with Human Abdominal Aortic Aneurysm"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1490-6474","authenticated-orcid":false,"given":"Anja","family":"Hofmann","sequence":"first","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surgery Faculty of Medicine andUniversity Hospital Carl Gustav Carus, Technische 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