{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:46:40Z","timestamp":1792079200675,"version":"4.4.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,3,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Recently, diastolic stress testing and invasive hemodynamic measurements have been emphasized for diagnosis of heart failure with preserved ejection fraction (HFpEF) because when determined using noninvasive parameters it can fall into a nondiagnostic intermediate range. The current study evaluated the discriminative and prognostic roles of invasive measured left ventricular end\u2010diastolic pressure in the population with suspected HFpEF, particularly for patients with intermediate Heart Failure Association Pre\u2010test Assessment, Echocardiography &amp; Natriuretic Peptide, Functional Testing, Final Etiology (HFA\u2010PEFF) score.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 404 patients with symptoms or signs of HF and preserved left ventricular systolic function were enrolled. All subjects underwent left heart catheterization with left ventricular end\u2010diastolic pressure measurement for confirmation of HFpEF (\u226516\u2009mm\u2009Hg). The primary outcome was all\u2010cause death or readmission due to HF within 10\u2009years. Among the study population, 324 patients (80.2%) were diagnosed as invasively confirmed HFpEF, and 80 patients (19.8%) were as noncardiac dyspnea. The patients with HFpEF showed a significantly higher HFA\u2010PEFF score than the patients with noncardiac dyspnea (3.8\u00b11.8 versus 2.6\u00b11.5,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The discriminative ability of the HFA\u2010PEFF score for diagnosing HFpEF was modest (area under the curve, 0.70 [95% CI, 0.64\u20130.75],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The HFA\u2010PEFF score was associated with a significantly higher 10\u2010year risk of death or HF readmission (per\u20101 increase, hazard ratio [HR], 1.603 [95% CI, 1.376\u20131.868],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Among the 226 patients with an intermediate HFA\u2010PEFF score (2\u20134), those with invasively confirmed HFpEF had a significantly higher risk of death or HF readmission within 10\u2009years than the patients with noncardiac dyspnea (24.0% versus 6.9%, HR, 3.327 [95% CI, 1.109\u201316.280],\n              <jats:italic>P<\/jats:italic>\n              =0.030).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The HFA\u2010PEFF score is a moderately useful tool for predicting future adverse events in suspected HFpEF, and invasively measured left ventricular end\u2010diastolic pressure can provide additional information to discriminate patient prognosis, particularly in those with intermediate HFA\u2010PEFF scores.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT04505449.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027581","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T11:37:20Z","timestamp":1678361840000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Discriminative Role of Invasive Left Heart Catheterization in Patients Suspected of Heart Failure With Preserved Ejection Fraction"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7511-9581","authenticated-orcid":false,"given":"Ki Hong","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8138-1367","authenticated-orcid":false,"given":"Jeong Hoon","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"},{"name":"Department of Critical Care Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2939-1714","authenticated-orcid":false,"given":"Jeong Hun","family":"Seo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Kangwon National University Hospital Chuncheon, Gangwon\u2010Do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0623-0486","authenticated-orcid":false,"given":"David","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4451-0435","authenticated-orcid":false,"given":"Taeho","family":"Youn","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2020-7028","authenticated-orcid":false,"given":"Hyun Sung","family":"Joh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-7826","authenticated-orcid":false,"given":"Seung Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiovascular Center Chonnam National University Hospital Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3284-0904","authenticated-orcid":false,"given":"Darae","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1440-3583","authenticated-orcid":false,"given":"Taek Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, 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