{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T03:28:59Z","timestamp":1794022139298,"version":"4.8.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,4,18]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Nighttime blood pressure (BP) and an abnormal nocturnal BP dipping profile are important cardiovascular risk factors in patients with hypertension. This post hoc analysis investigated the effects of sacubitril\/valsartan on 24\u2010hour BP in patients with mild\u2010to\u2010moderate hypertension and in patient subgroups based on nocturnal BP dipping status.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Data from a randomized clinical trial comparing the BP\u2010lowering effects of 8\u2009weeks of treatment with sacubitril\/valsartan (200 or 400\u2009mg\/d) and olmesartan (20\u2009mg\/d) in Japanese patients with mild\u2010to\u2010moderate hypertension were analyzed. The primary end point was change in 24\u2010hour, daytime, and nighttime BP in patient subgroups based on nocturnal BP dipping status (dipper, nondipper). Six hundred thirty\u2010two patients with baseline and follow\u2010up ambulatory BP data were included. Both sacubitril\/valsartan dosages reduced 24\u2010hour, daytime, and nighttime systolic BP, and 24\u2010hour and daytime diastolic BP, to a significantly greater extent than olmesartan in the dipper and nondipper groups. However, between\u2010group differences in nighttime systolic BP were more significant in the nondipper group (difference [95% CI] for sacubitril\/valsartan 200 and 400\u2009mg\/d versus olmesartan 20\u2009mg\/d: \u20134.6 [95% CI, \u22127.3 to \u22121.8] and \u22126.8 [95% CI, \u22129.5 to \u22124.1] mm\u2009Hg, respectively;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01 and\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Between\u2010group differences in the BP control rate were greatest in the nondipper subgroup (systolic BP control rate of 34.4% and 42.6% with sacubitril\/valsartan 200 and 400\u2009mg\/d versus 23.1% with olmesartan 20\u2009mg\/d).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">This analysis highlights the value of sacubitril\/valsartan therapy in patients with a nondipper profile of nocturnal BP and confirms this agent's potent 24\u2010hour BP\u2010lowering effect in Japanese populations with hypertension.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01599104.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027612","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T10:33:09Z","timestamp":1680863589000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Twenty\u2010Four\u2010Hour Blood Pressure\u2010Lowering Efficacy of Sacubitril\/Valsartan Versus Olmesartan in Japanese Patients With Essential Hypertension Based on Nocturnal Blood Pressure Dipping Status: A Post Hoc Analysis of Data From a Randomized, Double\u2010Blind Multicenter Study"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-4480","authenticated-orcid":false,"given":"Kazuomi","family":"Kario","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine Jichi Medical University School of Medicine Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-4338","authenticated-orcid":false,"given":"Hiromi","family":"Rakugi","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-2805","authenticated-orcid":false,"given":"Daisuke","family":"Yarimizu","sequence":"additional","affiliation":[{"name":"Medical Affairs Division Novartis Pharma K.K. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-8574","authenticated-orcid":false,"given":"Yohei","family":"Morita","sequence":"additional","affiliation":[{"name":"Medical Affairs Division Novartis Pharma K.K. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9512-1339","authenticated-orcid":false,"given":"Shunsuke","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Medical Affairs Division Novartis Pharma K.K. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8056-4281","authenticated-orcid":false,"given":"Kazuma","family":"Iekushi","sequence":"additional","affiliation":[{"name":"Medical Affairs Division Novartis Pharma K.K. 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Essential Manual of Perfect 24\u2010Hour Blood Pressure Management from Morning to Nocturnal Hypertension (in Press). London: Wiley; 2022."}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.027612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:50:48Z","timestamp":1715604648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.027612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,18]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,4,18]]}},"alternative-id":["10.1161\/JAHA.122.027612"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.027612","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,18]]},"assertion":[{"value":"2022-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e027612"}}