{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:21:40Z","timestamp":1781320900918,"version":"3.54.1"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,6,6]]},"abstract":"<jats:sec id=\"jah38482-sec-0001\" sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Previous randomized control trials showed mixed results concerning the effect of omega\u20103 fatty acids (n\u20103 FAs) on atrial fibrillation (AF). The associations of n\u20103 FA blood levels with heart rhythm in patients with established AF are unknown. The goal of this study was to assess the associations of total and individual n\u20103 FA blood levels with AF type (paroxysmal versus nonparoxysmal), heart rate (HR), and HR variability in patients with AF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah38482-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Total n\u20103 FAs, eicosapentaenoic acid, docosahexaenoic acid, docosapentaenoic acid, and alpha\u2010linolenic acid blood levels were determined in 1969 patients with known AF from the SWISS\u2010AF (Swiss Atrial Fibrillation cohort). Individual and total n\u20103 FAs were correlated with type of AF, HR, and HR variability using standard logistic and linear regression, adjusted for potential confounders. Only a mild association with nonparoxysmal AF was found with total n\u20103 FA (odds ratio [OR], 0.97 [95% CI, 0.89\u20131.05]) and docosahexaenoic acid (OR, 0.93 [95% CI, 0.82\u20131.06]), whereas other individual n\u20103 FAs showed no association with nonparoxysmal AF. Higher total n\u20103 FAs (estimate 0.99 [95% CI, 0.98\u20131.00]) and higher docosahexaenoic acid (0.99 [95% CI, 0.97\u20131.00]) tended to be associated with slower HR in multivariate analysis. Docosapentaenoic acid was associated with a lower HR variability triangular index (0.94 [95% CI, 0.89\u20130.99]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah38482-sec-0003\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">We found no strong evidence for an association of n\u20103 FA blood levels with AF type, but higher total n\u20103 FA levels and docosahexaenoic acid might correlate with lower HR, and docosapentaenoic acid with a lower HR variability triangular index.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027646","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T10:51:43Z","timestamp":1685616703000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Omega\u20103 Fatty Acids and Heart Rhythm, Rate, and Variability in Atrial Fibrillation"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1525-2019","authenticated-orcid":false,"given":"Philipp","family":"Baumgartner","sequence":"first","affiliation":[{"name":"Cantonal Hospital of Baden","place":["Baden, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9887-2469","authenticated-orcid":false,"given":"Martin F.","family":"Reiner","sequence":"additional","affiliation":[{"name":"Cantonal Hospital of Baden","place":["Baden, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8786-7915","authenticated-orcid":false,"given":"Andrea","family":"Wiencierz","sequence":"additional","affiliation":[{"name":"Clinical Trial Unit, University Hospital of Basel","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7678-7354","authenticated-orcid":false,"given":"Michael","family":"Coslovsky","sequence":"additional","affiliation":[{"name":"Clinical Trial Unit, University Hospital of Basel","place":["Basel, Switzerland"]},{"name":"University Hospital of Basel","place":["Basel, Switzerland"]},{"name":"University Hospital of Basel","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole R.","family":"Bonetti","sequence":"additional","affiliation":[{"name":"Cantonal Hospital of Baden","place":["Baden, Switzerland"]},{"name":"University of Zurich","place":["Schlieren, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Filipovic","sequence":"additional","affiliation":[{"name":"Bern University Hospital, University of Bern","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8134-2421","authenticated-orcid":false,"given":"Stefanie","family":"Aeschbacher","sequence":"additional","affiliation":[{"name":"University Hospital of Basel","place":["Basel, Switzerland"]},{"name":"University Hospital of Basel","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2937-3711","authenticated-orcid":false,"given":"Michael","family":"K\u00fchne","sequence":"additional","affiliation":[{"name":"University Hospital of Basel","place":["Basel, Switzerland"]},{"name":"University Hospital of Basel","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6625-284X","authenticated-orcid":false,"given":"Christine S.","family":"Zuern","sequence":"additional","affiliation":[{"name":"University Hospital of Basel","place":["Basel, Switzerland"]},{"name":"University Hospital of Basel","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9083-6896","authenticated-orcid":false,"given":"Nicolas","family":"Rodondi","sequence":"additional","affiliation":[{"name":"Bern University Hospital, University of Bern","place":["Switzerland"]},{"name":"University of Bern","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2988-3858","authenticated-orcid":false,"given":"Jolanda","family":"Oberle","sequence":"additional","affiliation":[{"name":"Bern University Hospital, University of Bern","place":["Switzerland"]},{"name":"University of Bern","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4043-8061","authenticated-orcid":false,"given":"Giorgio","family":"Moschovitis","sequence":"additional","affiliation":[{"name":"Ospedale Regionale di Lugano","place":["Lugano, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5259-538X","authenticated-orcid":false,"given":"Thomas F.","family":"L\u00fcscher","sequence":"additional","affiliation":[{"name":"Royal Brompton and Harefield Hospitals","place":["London, UK"]},{"name":"Imperial College","place":["London, UK"]},{"name":"University of Zurich","place":["Schlieren, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-0695","authenticated-orcid":false,"given":"Giovanni G.","family":"Camici","sequence":"additional","affiliation":[{"name":"University of Zurich","place":["Schlieren, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9240-6731","authenticated-orcid":false,"given":"Stefan","family":"Osswald","sequence":"additional","affiliation":[{"name":"University Hospital of Basel","place":["Basel, Switzerland"]},{"name":"University Hospital of Basel","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2459-5251","authenticated-orcid":false,"given":"David","family":"Conen","sequence":"additional","affiliation":[{"name":"McMaster University","place":["Hamilton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7199-0406","authenticated-orcid":false,"given":"J\u00fcrg H.","family":"Beer","sequence":"additional","affiliation":[{"name":"Cantonal Hospital of Baden","place":["Baden, Switzerland"]},{"name":"University of Zurich","place":["Schlieren, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the SWISS\u2010AF Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005119"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs253"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31257-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw007"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026847"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016075"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2017.33.1"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.11.055"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq501"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020651"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.971853"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2015.08.002"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90828-3"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.05.013"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.1489"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.052209"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22258"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812792"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.11.034"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.022194"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1735"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2011.00465.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2017.14467"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.039"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13553"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvab008"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.852657"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2018-000904"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.18.2452"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11122847"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091313"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-017-0052-3"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aimed.2019.04.003"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2004.02.030"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.11.048"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00416"},{"key":"e_1_3_2_39_2","first-page":"1","article-title":"Trends in the use of complementary health approaches among adults: United States, 2002\u20132012","volume":"79","author":"Clarke TC","year":"2015","unstructured":"Clarke TC, Black LI, Stussman BJ, Barnes PM, Nahin RL. Trends in the use of complementary health approaches among adults: United States, 2002\u20132012. Natl Health Stat Rep. 2015;79:1\u201316.","journal-title":"Natl Health Stat Rep"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.027646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T09:55:24Z","timestamp":1747130124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.027646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,6]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,6,6]]}},"alternative-id":["10.1161\/JAHA.122.027646"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.027646","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,6]]},"assertion":[{"value":"2022-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e027646"}}