{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:26:18Z","timestamp":1788056778481,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,2,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">High burden of premature ventricular complex (PVC) leads to increased cardiovascular mortality. A recent nationwide population\u2010based study demonstrated that PVC is associated with an increased risk of atrial fibrillation (AF). However, the relationship between PVC burden and new\u2010onset AF has not been investigated. The purpose of the study is to elucidate whether PVC burden is associated with new\u2010onset AF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We designed a single\u2010center, retrospective, large population\u2010based cohort study to evaluate the role of PVC burden and new\u2010onset AF in Taiwan. Patients who were AF na\u00efve with PVC were divided into the low burden group (&lt;1000\/day) and moderate\u2010to\u2010high burden group (\u22651000\/day) based on the 24\u2010h Holter ECG report. New\u2010onset AF was defined as a new or first detectable event of either a persistent or paroxysmal AF. A total of 16\u2009030 patients who were AF na\u00efve and underwent 24\u2010h Holter ECG monitoring were enrolled in this study, with a mean follow\u2010up time of 973\u2009days. A propensity score\u2010matched analysis demonstrated that the moderate\u2010to\u2010high burden PVC group had a higher risk of developing new\u2010onset AF than that of the low burden PVC group (4.91% versus 2.73%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Multivariate Cox regression analysis showed that moderate\u2010to\u2010high burden of PVC is an independent risk factor for new\u2010onset AF. The Kaplan\u2013Meier analysis demonstrated that patients with moderate\u2010to\u2010high PVC burden were associated with higher risk of new\u2010onset AF (log\u2010rank\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">PVC burden is associated with new\u2010onset AF. Patients with moderate\u2010to\u2010high PVC burden are at a higher risk of new\u2010onset AF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT03877614.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027674","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T12:16:51Z","timestamp":1676981811000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["High Burden of Premature Ventricular Complex Increases the Risk of New\u2010Onset Atrial Fibrillation"],"prefix":"10.1161","volume":"12","author":[{"given":"Po\u2010Tseng","family":"Lee","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Tainan Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4742-0056","authenticated-orcid":false,"given":"Mu\u2010Hsian","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan Taiwan"},{"name":"Department of Statistics, National Cheng Kung University Tainan 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Public Health, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2925-5352","authenticated-orcid":false,"given":"Sheng\u2010Hsian","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Tainan Taiwan"},{"name":"Biostatistics Consulting Center National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan Taiwan"},{"name":"Department of Public Health, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3643-5204","authenticated-orcid":false,"given":"Ping\u2010Yen","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Tainan Taiwan"},{"name":"Division of 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