{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:59:50Z","timestamp":1792479590869,"version":"4.5.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,1,17]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There have been limited data examining the age\u2010dependent relationship of wide\u2010range risk factors with the incidence of each subtype of cardiovascular disease (CVD) event. We assessed age\u2010related associations\u00a0between modifiable risk factors and the incidence of CVD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We analyzed 3\u2009027\u2009839 participants without a CVD history enrolled in the JMDC Claims Database (mean age, 44.8\u00b111.0\u2009years; 57.6% men). Each participant was categorized as aged 20 to 49\u2009years (n=2\u2009008\u2009559), 50 to 59\u2009years (n=712\u2009273), and 60 to 75\u2009years (n=307\u2009007). Using Cox proportional hazards models and the relative risk reduction, we identified associations between risk factors and incident CVD, consisting of myocardial infarction, angina pectoris, stroke, and heart failure (HF). We assessed whether the association of risk factors for developing CVD would be modified by age category. Over a mean follow\u2010up of 1133\u2009days, 6315 myocardial infarction, 56 447 angina pectoris, 28\u2009079 stroke, and 56\u2009369 HF events were recorded. The incidence of myocardial infarction, angina pectoris, stroke, and HF increased with age category. Hazard ratios of obesity, hypertension, and diabetes in the multivariable Cox regression analyses for myocardial infarction, angina pectoris, stroke, and HF decreased with age category. The relative risk reduction of obesity, hypertension, and diabetes for CVD events decreased with age category. For example, the relative risk reduction of hypertension for HF decreased from 59.2% in participants aged 20 to 49\u2009years to 38.1% in those aged 60 to 75\u2009years.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The contribution of modifiable risk factor to the development of CVD is greater in younger compared with older individuals. Preventive efforts for risk factor modification may be more effective in younger people.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027684","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T10:06:11Z","timestamp":1673431571000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Age\u2010Dependent Association Between Modifiable Risk Factors and Incident Cardiovascular Disease"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2553-6170","authenticated-orcid":false,"given":"Hidehiro","family":"Kaneko","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine The University of Tokyo Japan"},{"name":"Department of Advanced Cardiology The University of Tokyo 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