{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:30:38Z","timestamp":1790951438380,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Although high platelet reactivity (HPR) on clopidogrel is associated with higher ischemic events and lower bleeding events in patients who have undergone percutaneous coronary intervention with drug\u2010eluting stents, the differential risk of HPR in East Asian women versus men is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We compared 11\u2009714 patients enrolled in the PTRG\u2010DES (Platelet Function and Genotype\u2010Related Long\u2010Term Prognosis in Drug\u2010Eluting Stent\u2013Treated Patients With Coronary Artery Disease) Consortium according to sex and the presence\/absence of HPR on clopidogrel (defined as \u2265252 P2Y12 reactivity units). The primary study end point was major adverse cardiac and cerebrovascular events (MACCEs; comprising all\u2010cause mortality, myocardial infarction, cerebrovascular accident, and stent thrombosis). HPR was more common in women (46.7%) than in men (28.1%). In propensity\u2010adjusted models, HPR was an independent predictor of MACCEs (men with HPR: hazard ratio [HR], 1.60 [95% CI, 1.20\u20132.12]; women with HPR: HR, 0.99 [95% CI, 0.69\u20131.42]) and all\u2010cause mortality (men with HPR: HR, 1.61 [95% CI, 1.07\u20132.44]; women with HPR: HR, 0.92 [95% CI, 0.57\u20131.50]) in men, although those associations were insignificant among women. In addition, a significant interaction between sex was noted in the associations between HPR and MACCE (\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>interaction<\/jats:sub>\n              =0.013) or all\u2010cause mortality (\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>interaction<\/jats:sub>\n              =0.025).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this study, HPR was a differential risk factor for 1\u2010year MACCEs and all\u2010cause mortality in women and men. And it was an independent predictor of 1\u2010year MACCEs and all\u2010cause mortality in men but not in women.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT04734028. Registered July 9, 2003,\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04734028\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04734028<\/jats:ext-link>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027804","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T10:56:52Z","timestamp":1682765812000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Sex Differences in Midterm Prognostic Implications of High Platelet Reactivity After Percutaneous Coronary Intervention With Drug\u2010Eluting Stents in East Asian Patients: Results From the PTRG\u2010DES (Platelet Function and Genotype\u2010Related Long\u2010Term Prognosis in Drug\u2010Eluting Stent\u2013Treated Patients With Coronary Artery Disease) Consortium"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7539-8381","authenticated-orcid":false,"given":"Soo\u2010Jin","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Kosin University College of Medicine Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9990-6843","authenticated-orcid":false,"given":"Ae\u2010Young","family":"Her","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Kangwon National University School of Medicine Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0403-3726","authenticated-orcid":false,"given":"Young\u2010Hoon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Chung\u2010Ang University Thrombosis Center Gwangmyeong Chung\u2010Ang University Medical Center Gwangmyeong South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-066X","authenticated-orcid":false,"given":"Byeong\u2010Keuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1846-8464","authenticated-orcid":false,"given":"Hyung Joon","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Korea University Anam Hospital, Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3626-9717","authenticated-orcid":false,"given":"Yongwhi","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital Changwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3456-8705","authenticated-orcid":false,"given":"Kiyuk","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine College of Medicine, Catholic University of Korea Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3986-9152","authenticated-orcid":false,"given":"Young Bin","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1528-2739","authenticated-orcid":false,"given":"Sung Gyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Cardiology Yonsei University Wonju Severance Christian Hospital Wonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0397-6071","authenticated-orcid":false,"given":"Jung\u2010Won","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine and Department of Cardiology, Seoul National University Bundang Hospital Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1386-349X","authenticated-orcid":false,"given":"Sang Yeub","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Chungbuk National University, College of Medicine Cheongju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Rae","family":"Cho","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Internal Medicine Kangnam Sacred Heart Hospital, Hallym University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0847-5329","authenticated-orcid":false,"given":"Hyo\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiovascular Center Seoul National University Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3468-6453","authenticated-orcid":false,"given":"Moo Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Dong\u2010A University Hospital Busan South 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