{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:58:06Z","timestamp":1793383086871,"version":"4.5.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,3,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Heart failure is a public health issue worldwide. However, no comprehensive study on the global burden of heart failure and its contributing causes has been reported. The present study aimed to quantify the burden, trends, and inequalities of heart failure globally.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Heart failure data were extracted from the Global Burden of Diseases 2019 study. The number of cases, age\u2010standardized prevalence, and years lived with disability in different locations from 1990 to 2019 were presented and compared. Joinpoint regression analysis was performed to assess trends in heart failure from 1990 to 2019.<\/jats:p>\n            <jats:p xml:lang=\"en\">In 2019, the global age\u2010standardized prevalence and years lived with disability rates for heart failure were 711.90 (95% uncertainty interval [UI], 591.15\u2013858.29) and 63.92 (95% UI, 41.49\u201391.95) per 100\u2009000 population, respectively. In general, the age\u2010standardized rate decreased globally at an average annual percentage change of 0.3% (95% UI, 0.2\u20130.3). However, the rate increased at an average annual percentage change of 0.6% (95% UI, 0.4\u20130.8) from 2017 to 2019. Several nations and territories demonstrated an increased trend from 1990 to 2019, especially in less\u2010developed countries. Ischemic heart disease and hypertensive heart disease accounted for the highest proportion of heart failure in 2019.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Heart failure remains a major health problem, with increased trends possible in the future. Efforts for prevention and control of heart failure should focus more on less\u2010developed regions. It is essential to prevent and treat primary diseases such as ischemic heart disease and hypertensive heart disease for the control of heart failure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.027852","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T18:21:24Z","timestamp":1682619684000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":242,"title":["Burden, Trends, and Inequalities of Heart Failure Globally, 1990 to 2019: A Secondary Analysis Based on the Global Burden of Disease 2019 Study"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2464-2361","authenticated-orcid":false,"given":"Tao","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Zhongshan Hospital, Fudan University Shanghai 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