{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:19:31Z","timestamp":1790079571098,"version":"4.0.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,2,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Although chronic total occlusions (CTOs) are common in older adults, they are less likely to be offered CTO percutaneous coronary intervention for angina relief than younger adults. The health status impact of CTO percutaneous coronary intervention in adults aged \u226575\u2009years has not been studied. We sought to compare technical success rates and angina\u2010related health status outcomes at 12\u2009months between adults aged \u226575 and &lt;75\u2009years in the OPEN\u2010CTO (Outcomes, Patient Health Status, and Efficiency in Chronic Total Occlusion) registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Angina\u2010related health status was assessed with the Seattle Angina Questionnaire (score range 0\u2013100, higher scores denote less angina). Technical success rates were compared using hierarchical modified Poisson regression, and 12\u2010month health status was compared using hierarchical multivariable linear regression between adults aged \u226575 and &lt;75\u2009years. Among 1000 participants, 19.8% were \u226575\u2009years with a mean age of 79.5\u00b14.1\u2009years. Age \u226575\u2009years was associated with a lower likelihood of technical success (adjusted risk ratio=0.92 [95% CI, 0.86\u20130.99;\n                      <jats:italic>P<\/jats:italic>\n                      =0.02]) and numerically higher rates of in\u2010hospital major adverse cardiovascular events (9.1% versus 5.9%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.10). There was no difference in Seattle Angina Questionnaire Summary Score at 12\u2009months between adults aged \u226575 and &lt;75\u2009years (adjusted difference=0.9 [95% CI, \u22121.4 to 3.1;\n                      <jats:italic>P<\/jats:italic>\n                      =0.44]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Despite modestly lower success rates and higher complication rates, adults aged \u226575\u2009years experienced angina\u2010related health status benefits after CTO\u2010percutaneous coronary intervention that were similar in magnitude to adults aged &lt;75\u2009years. CTO percutaneous coronary intervention should not be withheld based on age alone in otherwise appropriate candidates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.122.027915","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T06:10:19Z","timestamp":1675145419000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Health Status Outcomes in Older Adults Undergoing Chronic Total Occlusion Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7025-4442","authenticated-orcid":false,"given":"Dan D.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute Kansas City MO"},{"name":"University of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2934-6913","authenticated-orcid":false,"given":"Kensey L.","family":"Gosch","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayan","family":"El\u2010Zein","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute Kansas City MO"},{"name":"University of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5185-3367","authenticated-orcid":false,"given":"Paul S.","family":"Chan","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute Kansas City MO"},{"name":"University of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Lombardi","sequence":"additional","affiliation":[{"name":"University of Washington Medical Center Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Karmpaliotis","sequence":"additional","affiliation":[{"name":"Morristown Medical Center Morristown NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2839-2611","authenticated-orcid":false,"given":"John A.","family":"Spertus","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute Kansas City MO"},{"name":"University of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4133-3042","authenticated-orcid":false,"given":"R. 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