{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T05:31:08Z","timestamp":1792992668676,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Anti\u2010cancer vascular endothelial growth factor inhibitors (VEGFI) frequently induce a rise in blood pressure (BP). The most effective treatment of this BP rise is currently unknown, and risk factors and its association with survival remain inconclusive.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Baseline characteristics and BP readings were retrospectively collected from oncology patients who received oral VEGFI treatment (sorafenib, sunitinib, pazopanib, regorafenib, lenvatinib, or cabozantinib). Risk factors for a clinically relevant BP rise (increase of \u226520\u2009mm\u2009Hg in systolic BP or \u226510\u2009mm\u2009Hg in diastolic BP) were investigated via logistic regression (relative), efficacy of antihypertensives via unpaired t\u2010tests, and association of BP rise with survival via Cox regression analysis. In total, 162 (47%) of 343 included patients developed a clinically relevant BP rise \u22657\u2009days after VEGFI treatment initiation. Both calcium channel blockers\u00a0and renin\u2010angiotensin system inhibitors\u00a0effectively reduced systolic BP (\u221224.1 and \u221218.2\u2009mm\u2009Hg, respectively) and diastolic BP (\u221212.0 and \u221211.0\u2009mm\u2009Hg, respectively). Pazopanib therapy (odds ratio, 2.71 [95% CI, 1.35\u20135.42;\n              <jats:italic>P<\/jats:italic>\n              =0.005], compared with sorafenib) and estimated glomerular filtration rate &lt;60\u2009mL\/min per 1.73\u2009m\n              <jats:sup>2<\/jats:sup>\n              (OR, 1.75 [95% CI, 0.99\u20133.18,\n              <jats:italic>P<\/jats:italic>\n              =0.054]) were risk factors for a BP rise, whereas a baseline BP \u2265140\/90\u2009mm\u2009Hg associated with a lower risk (OR, 0.39 [95% CI, 0.25\u20130.62,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001]). Only for renal cell carcinoma, BP rise was associated with a substantially improved median overall survival compared with no BP rise: 45.4 versus 20.3\u2009months, respectively,\n              <jats:italic>P<\/jats:italic>\n              =0.003.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The type of VEGFI, baseline BP, and baseline estimated glomerular filtration rate determine the VEGFI\u2010induced BP rise. Both calcium channel blockers\u00a0and renin\u2010angiotensin system inhibitors are effective antihypertensive treatments. Particularly in patients with renal cell carcinoma, a BP\u00a0rise is associated with improved overall survival.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.028050","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T10:37:36Z","timestamp":1672396656000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Treatment and Implications of Vascular Endothelial Growth Factor Inhibitor\u2010Induced Blood Pressure Rise: A Clinical Cohort Study"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6817-9156","authenticated-orcid":false,"given":"Daan C. H.","family":"van Dorst","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Erasmus MC Cancer Institute Erasmus MC University Medical Center Rotterdam The Netherlands"},{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8919-1867","authenticated-orcid":false,"given":"Sumeyye","family":"Kabadayi","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2506-3852","authenticated-orcid":false,"given":"Esther","family":"Oomen\u2010de Hoop","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Erasmus MC Cancer Institute Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-3585","authenticated-orcid":false,"given":"A.H. Jan","family":"Danser","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5667-5697","authenticated-orcid":false,"given":"Ron H. J.","family":"Mathijssen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Erasmus MC Cancer Institute Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-7765","authenticated-orcid":false,"given":"Jorie","family":"Versmissen","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine Erasmus MC University Medical Center Rotterdam The Netherlands"},{"name":"Department of Hospital Pharmacy Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20200300"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-018-0056-z"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.07.025"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0058"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12052"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-011-0201-x"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq091"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw211"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4783"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04187"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-010-9549-5"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2016.10.004"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr128"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.08.002"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28972"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016347"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.06.021"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.160481"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318051"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.136"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab674"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-009-1170-y"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181fa8efd"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.06.081"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.08856"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-017-0510-z"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32964"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.05.055"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.149690"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001894"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.2273"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.028050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T13:00:30Z","timestamp":1715605230000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.028050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,3]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,3]]}},"alternative-id":["10.1161\/JAHA.122.028050"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.028050","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,3]]},"assertion":[{"value":"2022-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e028050"}}