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Here, we review the biomechanical and mechanobiological impact of left heart failure on pulmonary circulation, including mechanotransduction of these pathological forces, which lead to altered biological signaling and detrimental remodeling, driving the progression to Cpc\u2010PH. We focus on pathologically increased cyclic stretch and decreased wall shear stress; mechanotransduction by endothelial cells, smooth muscle cells, and pulmonary arterial fibroblasts; and signaling\u2010stimulated remodeling of the pulmonary veins, capillaries, and arteries that propel the transition from Ipc\u2010PH to Cpc\u2010PH. Identifying biomechanical and mechanobiological mechanisms of Cpc\u2010PH progression may highlight potential pharmacologic avenues to prevent right heart failure and subsequent mortality.<\/jats:p>","DOI":"10.1161\/jaha.122.028121","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T11:30:02Z","timestamp":1675423802000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Biomechanical and Mechanobiological Drivers of the Transition From PostCapillary Pulmonary Hypertension to Combined Pre\u2212\/PostCapillary Pulmonary Hypertension"],"prefix":"10.1161","volume":"12","author":[{"given":"Betty J.","family":"Allen","sequence":"first","affiliation":[{"name":"Department of Surgery University of Wisconsin\u2010Madison Madison WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey","family":"Frye","sequence":"additional","affiliation":[{"name":"Department of Biomedical 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