{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:00:34Z","timestamp":1769119234261,"version":"3.49.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,3,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">In acute intracerebral hemorrhage, both elevated blood pressure (BP) and antithrombotic treatment are associated with poor outcome. Our aim was to explore interactions between antithrombotic treatment and prehospital BP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This observational, retrospective study included adult patients with spontaneous intracerebral hemorrhage diagnosed by computed tomography within 24\u2009hours, admitted to a primary stroke center during 2012 to 2019. The first recorded prehospital\/ambulance systolic and diastolic BP were analyzed per 5\u2009mm\u2009Hg increment. Clinical outcomes were in\u2010hospital mortality, shift on the modified Rankin Scale at discharge, and mortality at 90\u2009days. Radiological outcomes were initial hematoma volume and hematoma expansion. Antithrombotic (antiplatelet and\/or anticoagulant) treatment was analyzed both together and separately. Modification of associations between prehospital BP and outcomes by antithrombotic treatment was explored by multivariable regression with interaction terms. The study included 200 women and 220 men, median age 76 (interquartile range, 68\u201385)\u00a0years. Antithrombotic drugs were used by 252 of 420 (60%) patients. Compared with patients without, patients with antithrombotic treatment had significantly stronger associations between high prehospital systolic BP and in\u2010hospital mortality (odds ratio [OR], 1.14 versus 0.99,\n              <jats:italic>P<\/jats:italic>\n              for interaction 0.021), shift on the modified Rankin Scale (common OR, 1.08 versus 0.96,\n              <jats:italic>P<\/jats:italic>\n              for interaction 0.001), and hematoma volume (coef. 0.03 versus \u22120.03,\n              <jats:italic>P<\/jats:italic>\n              for interaction 0.011).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with acute, spontaneous intracerebral hemorrhage, antithrombotic treatment modifies effects of prehospital BP. Compared with patients without, patients with antithrombotic treatment have poorer outcomes with higher prehospital BP. These findings may have implications for future studies on early BP lowering in intracerebral hemorrhage.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.028336","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T02:29:16Z","timestamp":1677983356000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Antithrombotic Treatment, Prehospital Blood Pressure, and Outcomes in Spontaneous Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1310-8243","authenticated-orcid":false,"given":"Kristin Tveitan","family":"Larsen","sequence":"first","affiliation":[{"name":"Department of Neurology Akershus University Hospital L\u00f8renskog Norway"},{"name":"Department of Geriatric Medicine Oslo University Hospital Oslo Norway"},{"name":"University of Oslo, Institute of Clinical Medicine Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4312-4778","authenticated-orcid":false,"given":"Else Charlotte","family":"Sandset","sequence":"additional","affiliation":[{"name":"Department of Neurology Oslo University Hospital Oslo Norway"},{"name":"The Norwegian Air Ambulance Foundation Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiken Nordahl","family":"Selseth","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3008-5159","authenticated-orcid":false,"given":"Silje Holt","family":"Jahr","sequence":"additional","affiliation":[{"name":"Department of Neurology Akershus University Hospital L\u00f8renskog Norway"},{"name":"University of Oslo, Institute of Clinical Medicine Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nojoud","family":"Koubaa","sequence":"additional","affiliation":[{"name":"Department of Neurology Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vigdis","family":"Hillestad","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8999-5424","authenticated-orcid":false,"given":"Espen Saxhaug","family":"Kristoffersen","sequence":"additional","affiliation":[{"name":"Department of Neurology Akershus University Hospital L\u00f8renskog Norway"},{"name":"Department of General Practice University of Oslo, Institute of Health and Society Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-5788","authenticated-orcid":false,"given":"Ole Morten","family":"R\u00f8nning","sequence":"additional","affiliation":[{"name":"Department of Neurology Akershus University Hospital L\u00f8renskog Norway"},{"name":"University of Oslo, Institute of Clinical Medicine Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12180"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000128795.38283.4b"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.1.21"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873211012133"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000069"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-327195"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30253-9"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214609"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603460"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018485"},{"key":"e_1_3_2_12_2","article-title":"Prehospital systolic hypertension and outcomes in patients with spontaneous intracerebral hemorrhage","volume":"9","author":"Hatcher S","year":"2017","unstructured":"Hatcher S, Chen C, Govindarajan P. 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