{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:27:56Z","timestamp":1778304476231,"version":"3.51.4"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,5,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Small spotty calcifications in the coronary arteries are associated with an increased risk of myocardial infarction. We examined the association between spotty calcifications near the carotid bifurcations and ipsilateral ischemic stroke in patients with &lt;50% luminal stenosis of the extracranial carotid arteries.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We used data from the CAESAR (Cornell Acute Stroke Academic Registry), a prospective registry of all patients with acute ischemic stroke admitted to our institution. We included patients who met criteria for cryptogenic stroke and underwent computed tomography angiography and brain magnetic resonance imaging. Patients with extracranial carotid artery stenosis \u226550% and patients with posterior or bilateral anterior circulation infarcts were excluded. We examined the carotid bifurcations for spotty calcifications, defined as \u22651 contiguous regions of luminal calcification \u22643\u2009mm along the long axis of the vessel. We also measured low\u2010density plaque and maximum plaque thickness. The eligible cohort consisted of 117 patients with a mean age of 66.7\u00b11.65\u2009years with a median National Institute of Health Stroke Scale stroke at the time of arrival of 6 (range, 3\u201313). The number of spotty calcifications present within a low\u2010density plaque was significantly associated with ipsilateral infarction (0.3\u00b10.8 versus 0.1\u00b10.4,\n              <jats:italic>P<\/jats:italic>\n              =0.02). Maximum plaque thickness was also significantly associated with ipsilateral infarction (1.4\u2009mm \u00b11.5 versus 1.0\u2009mm \u00b11.1,\n              <jats:italic>P<\/jats:italic>\n              =0.004).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Spotty calcifications associated with low\u2010density plaque and maximum plaque thickness were associated with ipsilateral ischemic stroke in patients with nonstenotic carotid atherosclerosis, suggesting a role as imaging markers of high\u2010risk plaque.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.028525","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:12:25Z","timestamp":1684145545000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Association Between Spotty Calcification in Nonstenosing Extracranial Carotid Artery Plaque and Ipsilateral Ischemic Stroke"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4616-9819","authenticated-orcid":false,"given":"Moayad","family":"Homssi","sequence":"first","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5905-1303","authenticated-orcid":false,"given":"Amar","family":"Vora","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8137-1644","authenticated-orcid":false,"given":"Cenai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6251-5769","authenticated-orcid":false,"given":"Hediyeh","family":"Baradaran","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences University of Utah Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5745-0307","authenticated-orcid":false,"given":"Hooman","family":"Kamel","sequence":"additional","affiliation":[{"name":"Brain Mind Institute, Weill Cornell Medicine New York NY USA"},{"name":"Department of Neurology, Weill Cornell Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-0340","authenticated-orcid":false,"given":"Ajay","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine New York NY USA"},{"name":"Brain Mind Institute, Weill Cornell Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3238165"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00058"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5436"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023273"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000148131.41425.E9"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.659156"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014818"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.9.1751"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003882"},{"key":"e_1_3_1_12_2","unstructured":"Stata Statistical Software: Release 15 . Stata.com StataCorp LLC; June 2017. January 2022. https:\/\/www.stata.com\/stata15\/"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2078"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2009.03.009"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.184.1.01840295"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.02.010"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-014-0084-y"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020143"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6160"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3228"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2018.08.070"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000101746"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.035692"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4098"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4765"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023987"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.004976"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.028525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:33:46Z","timestamp":1715603626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.028525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,5,16]]}},"alternative-id":["10.1161\/JAHA.122.028525"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.028525","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]},"assertion":[{"value":"2022-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e028525"}}