{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:57:34Z","timestamp":1792569454809,"version":"4.5.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,4,18]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Transthyretin amyloid cardiomyopathy (ATTR\u2010CM) is an important cause of heart failure in older individuals. Misfolding and deposition of transthyretin or prealbumin protein causes ATTR\u2010CM in the context of a normal (wild\u2010type) or variant\n                      <jats:italic>TTR<\/jats:italic>\n                      sequence. Variant ATTR\u2010CM is most commonly caused by the substitution of valine for isoleucine at position 122 in transthyretin (Val122Ile or pV142I, almost exclusively observed in individuals of West African ancestry), demonstrated in 3.4% of self\u2010identified Black individuals in the United States with an estimated 1.5\u2009million carriers. Despite the large number of known pV142I carriers, the proportion of older Black patients with heart failure attributable to ATTR\u2010CM remains unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\" xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      To address this knowledge gap, the SCAN\u2010MP (Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations) study was funded by the National Institutes of Health\/National Heart, Lung, and Blood Institute (R01HL139671) to enroll a targeted population of self\u2010identified, community\u2010dwelling Black or Caribbean Hispanic patients (many of whom are of West African ancestry) &gt;60\u2009years of age with heart failure and identify ATTR\u2010CM by noninvasive nuclear imaging. The principal objective of SCAN\u2010MP is to determine the prevalence of ATTR\u2010CM in this population. Secondary objectives will explore\n                      <jats:italic>TTR<\/jats:italic>\n                      genotype, demographics, progression of variant versus wild\u2010type ATTR\u2010CM, and biochemical mechanisms of transthyretin amyloid fibril formation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The SCAN\u2010MP study is the largest, prospective study of cardiac amyloidosis in Black and Hispanic individuals. Both wild\u2010type and variant ATTR\u2010CM are now treatable with the US Food and Drug\u2013approved drug tafamidis. The insights gained from SCAN\u2010MP are likely to improve those at risk for or afflicted with ATTR\u2010CM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT03812172.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.122.028534","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T05:10:43Z","timestamp":1681708243000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Design and Rationale the SCAN\u2010MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-4413","authenticated-orcid":false,"given":"Frederick L.","family":"Ruberg","sequence":"first","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Medicine Boston University Chobanian &amp; Avedisian School of Medicine Boston Medical Center Boston MA USA"},{"name":"Amyloidosis Center Boston University Chobanian &amp; Avedisian School of Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Blaner","sequence":"additional","affiliation":[{"name":"Department of Medicine Vagelos College of Physicians and Surgeons Columbia University Irving Medical Center New York 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