{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:56:49Z","timestamp":1790740609555,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,6,6]]},"abstract":"<jats:sec id=\"jah38378-sec-0001\" sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Fixed\u2010dose combination (FDC) antihypertensive products improve blood pressure control and adherence among patients with hypertension. It is unknown to what degree commercially available FDC products meet the current hypertension management prescription patterns in the United States.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah38378-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">This cross\u2010sectional analysis of the National Health and Nutrition Examination Surveys 2015 to March 2020 included participants with hypertension taking \u22652 antihypertensive medications (N=2451). After constructing each participant's regimen according to antihypertensive classes used, we estimated the extent to which the 7 class\u2010level FDC regimens available in the United States as of January 2023 would match the regimens used. Among a weighted population of 34.1 million US adults (mean age, 66.0\u2009years; 52.8% women; 69.1% non\u2010Hispanic White race and ethnicity), the proportions using 2, 3, 4, and \u22655 antihypertensive classes were 60.6%, 28.2%, 9.1%, and 1.6%, respectively. The 7 FDC regimens were among 189 total regimens used (3.7%). Overall, 52.7% (95% confidence interval [CI], 48.5%\u201057.0%, 18.0 million US adults) of the population were taking a regimen that was available as a class equivalent FDC product, and 47.3% (95% CI, 43.0\u201051.5%, 16.1 million US adults) were using a regimen not available as a class\u2010equivalent FDC product.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah38378-sec-0003\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">About half of US adults with hypertension taking \u22652 antihypertensive classes are using a regimen that is not commercially available as a class\u2010equivalent FDC product as of January 2023. To maximize the potential benefit of FDCs to improve medication adherence (and thus blood pressure control) among patients taking multiple antihypertensive medications, use of FDC\u2010compatible regimens and improvements in the product landscape are needed.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.028573","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T10:56:20Z","timestamp":1683629780000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Antihypertensive Medication Regimens Used by US Adults With Hypertension and the Potential for Fixed\u2010Dose Combination Products: The National Health and Nutrition Examination Surveys 2015 to 2020"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7382-4607","authenticated-orcid":false,"given":"Catherine G.","family":"Derington","sequence":"first","affiliation":[{"name":"University of 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