{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:46:27Z","timestamp":1789778787973,"version":"4.0.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Pregnancy loss has been associated with myocardial infarction, stroke, and all\u2010cause mortality in women through unknown mechanisms. The aim of this study was to examine these associations in women and their male partners.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">In this register\u2010based cohort study, all people born between 1957 and 1997, residing in Denmark between 1977 and 2017, and with a registered partner of the opposite sex were eligible for inclusion. Male partners through cohabitation, marriage, or paternity constituted the male cohort. Exposure to pregnancy loss was categorized as follows: 0, 1, 2, or \u22653 pregnancy losses. The outcomes of interest were myocardial infarction, stroke, and all\u2010cause mortality. The Cox proportional hazards model estimated hazard ratios (HRs), adjusted for age, calendar year, parity, and parental history of myocardial infarction or stroke.<\/jats:p>\n            <jats:p xml:lang=\"en\">During follow\u2010up, 1\u2009112\u2009507 women experienced 4463 events of myocardial infarction compared with 13\u2009838 events among 1\u2009120\u2009029 male partners. With the no pregnancy loss group as reference, the adjusted HRs of myocardial infarction in the female cohort after 1, 2, and \u22653 pregnancy losses were as follows: 1.1 (95% CI, 1.0\u20131.2), 1.3 (95% CI, 1.1\u20131.5), and 1.4 (95% CI, 1.1\u20131.8), respectively. In the male partner cohort, the corresponding estimates were 1.0 (95% CI, 1.0\u20131.1), 1.1 (95% CI, 1.0\u20131.2), and 1.0 (95% CI, 0.8\u20131.2), respectively. The outcome of stroke showed similar results. Pregnancy loss was not significantly associated with increased mortality in either sex.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Pregnancy loss or stillbirth was significantly associated with myocardial infarction and stroke in women but not their male partners. Pregnancy loss or stillbirth was not significantly associated with all\u2010cause mortality in women or male partners.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.028620","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T11:32:30Z","timestamp":1690284750000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Pregnancy Loss and the Risk of Myocardial Infarction, Stroke, and All\u2010Cause Mortality: A Nationwide Partner Comparison Cohort Study"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7583-9826","authenticated-orcid":false,"given":"Anders Pretzmann","family":"Mikkelsen","sequence":"first","affiliation":[{"name":"Department of Gynaecology Copenhagen University Hospital\u2013Rigshospitalet Copenhagen Denmark"},{"name":"Department of Obstetrics and Gynaecology Copenhagen University Hospital Herlev Herlev 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