{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:04:57Z","timestamp":1784761497161,"version":"3.55.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,4,18]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Ambulatory blood pressure (BP) monitoring has long been used to monitor BP in hypertension and lately emerged as a useful tool to detect hypotensive susceptibility in reflex syncope. However, hemodynamic characteristics in reflex syncope have not been sufficiently explored. The present study investigated the differences between ambulatory BP monitoring profiles associated with reflex syncope and normal population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This is an observational study comparing ambulatory BP monitoring data from 50 patients with reflex syncope and 100 controls without syncope, age\u2010 and sex\u2010matched 1:2. Mean 24\u2010hour systolic (SBP) and diastolic BP, pulse pressure (24\u2010hour PP), dipping status, and number of daytime SBP drops &lt;90 to 100\u2009mm\u2009Hg were analyzed. Variables associated with reflex syncope were investigated using multivariable logistic regression. Patients with reflex syncope displayed significantly lower 24\u2010hour SBP (112.9\u00b112.6 versus 119.3\u00b111.5\u2009mm\u2009Hg,\n              <jats:italic>P<\/jats:italic>\n              =0.002), higher 24\u2010hour diastolic BP (85.2\u00b19.6 versus 79.1\u00b110.6\u2009mm\u2009Hg,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and markedly lower 24\u2010hour PP (27.7\u00b17.6 versus 40.3\u00b19.0\u2009mm\u2009Hg,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) compared with controls. Daytime SBP drops &lt;90\u2009mm\u2009Hg were more prevalent in patients with syncope (44% versus 17%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Daytime SBP drops &lt;90\u2009mm\u2009Hg, 24\u2010hour PP &lt;32\u2009mm\u2009Hg, 24\u2010hour SBP \u2264110\u2009mm\u2009Hg, and 24\u2010hour diastolic BP \u226582\u2009mm\u2009Hg were independently associated with reflex syncope, with 24\u2010hour PP &lt;32\u2009mm\u2009Hg achieving the highest sensitivity (80%) and specificity (86%).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients with reflex syncope have lower 24\u2010hour SBP but higher 24\u2010hour diastolic BP and more frequent daytime SBP drops &lt;90\u2009mm\u2009Hg than individuals without syncope. Our results support the presence of lower SBP and PP in reflex syncope and suggest a role for ambulatory BP monitoring in the diagnostic work\u2010up of this condition.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.028704","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T10:34:57Z","timestamp":1680863697000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Twenty\u2010Four\u2010Hour Ambulatory Blood Pressure Profile in Patients With Reflex Syncope and Matched Controls"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-5902","authenticated-orcid":false,"given":"Bashaaer","family":"Sharad","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund University, and Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-2242","authenticated-orcid":false,"given":"Giulia","family":"Rivasi","sequence":"additional","affiliation":[{"name":"Division of Geriatric and Intensive Care Medicine University of Florence and Azienda Ospedaliero Universitaria Careggi Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8475-0866","authenticated-orcid":false,"given":"Viktor","family":"Hamrefors","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University, and Sk\u00e5ne University Hospital Malm\u00f6 Sweden"},{"name":"Department of Cardiology Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9057-9148","authenticated-orcid":false,"given":"Madeleine","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University, and Sk\u00e5ne University Hospital Malm\u00f6 Sweden"},{"name":"Department of Cardiology Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8965-4523","authenticated-orcid":false,"given":"Andrea","family":"Ungar","sequence":"additional","affiliation":[{"name":"Division of Geriatric and Intensive Care Medicine University of Florence and Azienda Ospedaliero Universitaria Careggi Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5710-1094","authenticated-orcid":false,"given":"Richard","family":"Sutton","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University, and Sk\u00e5ne University Hospital Malm\u00f6 Sweden"},{"name":"Department of Cardiology, National Heart &amp; Lung Institute, Imperial College Hammersmith Hospital Campus London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1845-5607","authenticated-orcid":false,"given":"Michele","family":"Brignole","sequence":"additional","affiliation":[{"name":"IRCCS, Istituto Auxologico Italiano, Cardiology Unit S.Luca Hospital Milan Italy"},{"name":"Department of Cardiovascular, Neural and Metabolic Sciences S.Luca Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9402-7439","authenticated-orcid":false,"given":"Gianfranco","family":"Parati","sequence":"additional","affiliation":[{"name":"IRCCS, Istituto Auxologico Italiano, Cardiology Unit S.Luca Hospital Milan Italy"},{"name":"Department of Cardiovascular, Neural and Metabolic Sciences S.Luca Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5352-6327","authenticated-orcid":false,"given":"Artur","family":"Fedorowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University, and Sk\u00e5ne University Hospital Malm\u00f6 Sweden"},{"name":"Department of Cardiology Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Medicine Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy037"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.116.003202"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00533.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-021-02065-7"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206936"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002843"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-318261"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu255"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac347"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002800"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-020-00695-4"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-97503-0"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.962332"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-011-0134-6"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.15.6.875"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14207"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.102.23.2898"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2008.01229.x"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.028704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:49:10Z","timestamp":1715604550000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.028704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,18]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,4,18]]}},"alternative-id":["10.1161\/JAHA.122.028704"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.028704","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,18]]},"assertion":[{"value":"2022-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e028704"}}