{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T20:35:53Z","timestamp":1785098153998,"version":"3.55.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,5,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">To promote ideal cardiovascular health, the American Heart Association recommends adhering to Life's Simple 7 (LS7)\u2014achieving healthy targets for body mass index, physical activity, dietary intake, blood pressure, fasting plasma glucose, and cholesterol, along with smoking abstinence. Poorer achievement of LS7 (lower score) has been associated with the development of hypertension and cardiovascular disease. However, less is known about the associations between LS7 and specific biomarkers linked to cardiovascular health: aldosterone, CRP (C\u2010reactive protein), and IL\u20106 (interleukin\u20106).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We analyzed 379 individuals (age 18\u201366\u2009years) from the HyperPATH (International Hypertensive Pathotype), who were maintained on \u2265200\u2009mEq of sodium daily for 1\u2009week. We calculated a 14\u2010point summative LS7 score according to participants' baseline data. Based on the range of LS7 score in this population (3\u201314), we classified participants as \u201cinadequate\u201d (3\u20136), \u201caverage\u201d (7\u201310), and \u201coptimal\u201d (11\u201314). Regression analyses found that a higher LS7 score group was associated with lower levels of serum and urinary aldosterone (\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              &lt;0.001 and\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              =0.001, respectively), lower plasma renin activity (\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              &lt;0.001), and a blunted increase in serum aldosterone with angiotensin II infusion (\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              =0.023). Being in the \u201coptimal\u201d LS7 score group was associated with lower serum CRP (\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              =0.001) and IL\u20106 (\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              =0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">A higher LS7 score was associated with a lower activity of the renin\u2010angiotensin\u2010aldosterone system and lower levels of the inflammatory markers CRP and IL\u20106. These findings offer a possible link between ideal cardiovascular health targets and biomarkers known to play a central role in the development of cardiovascular disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.028718","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T11:55:59Z","timestamp":1683633359000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Association Between Life's Simple 7 and Biomarkers of Cardiovascular Disease: Aldosterone, Interleukin\u20106, C\u2010Reactive Protein"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9105-7154","authenticated-orcid":false,"given":"Yan Emily","family":"Yuan","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8044-7926","authenticated-orcid":false,"given":"Andrea V.","family":"Haas","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-1093","authenticated-orcid":false,"given":"Gordon H.","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Taylor","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Morehouse School of Medicine Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen W.","family":"Seely","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3506-7347","authenticated-orcid":false,"given":"Gail K.","family":"Adler","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000677"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001031"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312669"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-19-0323"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192703"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008741"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09278"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016482"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15890"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11050955"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpy120"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac027"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa606"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2165\/00129784-200707030-00001"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2025845"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411001"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2110956"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-017-0266-5"},{"key":"e_1_3_2_20_2","first-page":"225","article-title":"The impact of C reactive protein on global cardiovascular risk on patients with coronary artery disease","volume":"39","author":"Cozlea DL","year":"2013","unstructured":"Cozlea DL, Farcas DM, Nagy A, Keresztesi AA, Tifrea R, Cozlea L, Cara\u0219ca E. 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