{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:45:15Z","timestamp":1790718315482,"version":"4.1.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,4,4]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Frailty and cognitive impairment are common in the elderly, with various shared risk factors like hypertension. Frailty is a marker for future cognitive function. Moreover, whether intensive blood pressure interacted with frailty and cognitive impairment is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We performed a post hoc analysis of data from SPRINT (Systolic Blood Pressure Intervention Trial). The relationship between frailty and a composite of probable dementia (PD) and mild cognitive impairment (MCI) was analyzed. Also, we evaluated the interaction of intensive blood pressure lowering in the relationship between frailty and cognitive impairment. A total of 8537 patients were included in our study, and 35.1% were women. The mean age of these participants was 67.9\u00b19.3\u2009years. According to the baseline frailty index, 1670, 4637, and 2230 patients were in fit, less fit, and frail statuses, respectively. During a mean follow\u2010up of 4.61\u2009years, 871 cases of PD or MCI occurred. Compared with those in fit status, those with less fit (hazard ratio [HR], 2.14 [95% CI, 1.65\u20132.77]) and frailty (HR, 4.28 [95% CI, 3.26\u20135.61]) status had a higher incidence of a composite of PD and MCI. Blood pressure control strategy interacted with the correlation between frailty and cognitive impairment. Intensive blood pressure control (HR, 2.4 [95% CI, 2.0\u20132.8]) accelerated the relationship between frailty and incidence of PD and MCI compared with the standard treatment group (HR, 1.8 [95% CI, 1.5\u20132.1];\n              <jats:italic>P<\/jats:italic>\n              for interaction=0.009).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">This study found that the baseline frailty status was a possible marker for the incidence of a composite of PD and MCI. Intensive blood pressure control may strengthen this correlation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/\">https:\/\/clinicaltrials.gov\/<\/jats:ext-link>\n              ; Unique identifier: NCT01206062.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.028736","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T09:23:21Z","timestamp":1679995401000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Association Between the Frailty and Cognitive Impairment Among Patients With\u00a0Hypertension\u2014A Post Hoc Analysis of\u00a0the SPRINT Trial"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1404-2696","authenticated-orcid":false,"given":"Zhiyan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Beijing Anzhen Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinshi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Changzhou No.2 People\u2019s Hospital, Nanjing Medical University Changzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7667-885X","authenticated-orcid":false,"given":"Junyu","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Xiangya Hospital, Central South University Changsha Hunan China"},{"name":"Department of Biochemistry and Molecular Biology The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences Center Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Xiangya Hospital, Central South University Changsha Hunan China"},{"name":"Department of Biochemistry and Molecular Biology The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences Center Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health Brown University Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2029-6657","authenticated-orcid":false,"given":"Jiafu","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Yangzhou University, Yangzhou University Yangzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7463-8707","authenticated-orcid":false,"given":"Xin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Beijing Anzhen Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2013.06.004"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.m146"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-015-0140-3"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/62.7.738"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv228"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21442"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1740774514537404"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004479-200610000-00007"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00249-8"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-327396"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-021-02104-3"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610220003932"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.05.013"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2022.01.084"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1198-x"},{"key":"e_1_3_1_21_2","first-page":"179","article-title":"Cerebral small vessel disease, cognitive impairment and vascular dementia","volume":"54","author":"Sierra C","year":"2012","unstructured":"Sierra C. Cerebral small vessel disease, cognitive impairment and vascular dementia. Panminerva Med. 2012;54:179\u2013188.","journal-title":"Panminerva Med"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.18.2046"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70143-1"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.13656"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16272"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa303"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.028736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:52:24Z","timestamp":1715604744000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.028736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,4]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,4,4]]}},"alternative-id":["10.1161\/JAHA.122.028736"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.028736","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,4]]},"assertion":[{"value":"2022-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e028736"}}