{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:33:20Z","timestamp":1791671600251,"version":"4.3.4"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,4,4]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The 10\u2010year and lifetime cardiovascular disease risk in the population with stage 1 hypertension and the effects of recovery from and progression of stage 1 hypertension remain undetermined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">This prospective cohort study included 96\u2009268 individuals with blood pressure measurements obtained in 2006 and again in 2010. The 10\u2010year cardiovascular disease risk was estimated using the multivariable Cox proportional hazards model, and the lifetime risk was calculated using a modified survival analysis that accounted for the competing risk of death. Stage 1 hypertension was detected in 30.83% of the cohort. The 10\u2010year cardiovascular disease risk was 2.80%, and the lifetime risk was 16.61%. Compared with the normal blood pressure group, the stage 1 hypertension group had a 35% higher 10\u2010year risk (hazard ratio [HR], 1.35 [95% CI, 1.19\u20131.52]) and a 36% higher lifetime risk (HR, 1.36 [95% CI, 1.25\u20131.49]). By 2010, 12.57% of the participants with stage 1 hypertension had progressed to stage 2, with a significant 156% increase in 10\u2010year risk (HR, 2.56 [95% CI, 2.11\u20133.11]) and an increased lifetime risk of 129% (HR, 2.29 [95% CI, 1.89\u20132.77]). There was no appreciable change in risk in those with stage 1 hypertension whose blood pressure returned to the normal\u2010elevated range.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Stage 1 hypertension was associated with a significant increase in 10\u2010year and lifetime cardiovascular disease risk. Progression to stage 2 hypertension was associated with a marked increase in lifetime risk. The current guidelines require revision to promote early detection and appropriate management of blood pressure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.122.028762","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T07:33:25Z","timestamp":1679988805000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Stage 1 Hypertension and the 10\u2010Year and Lifetime Risk of Cardiovascular Disease: A Prospective Real\u2010World Study"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6003-2392","authenticated-orcid":false,"given":"Xinyi","family":"Peng","sequence":"first","affiliation":[{"name":"Hypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases of China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0903-1685","authenticated-orcid":false,"given":"Cheng","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Public Health and Emergency Management Southern University of Science and Technology Shenzhen China"},{"name":"School of Medicine Southern University of Science and Technology Shenzhen China"},{"name":"Department of Cardiology Kailuan General Hospital Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qirui","family":"Song","sequence":"additional","affiliation":[{"name":"Hypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases of China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-6022","authenticated-orcid":false,"given":"Shouling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kailuan General Hospital Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-9570","authenticated-orcid":false,"given":"Jun","family":"Cai","sequence":"additional","affiliation":[{"name":"Hypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases of China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30752-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318083"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000066"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-017-0789-z"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.06.056"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.13551"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15026"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032380"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12396"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18305"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.038"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv079"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.001"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.10.1407"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(20000615\/30)19:11\/12<1495::AID-SIM441>3.0.CO;2-E"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31694-5"},{"key":"e_1_3_2_20_2","first-page":"8","article-title":"ACC\/AHA blood pressure classification and cardiovascular disease in 15 million adults of age 20\u201394\u2009years","volume":"2019","author":"Lee H","year":"2017","unstructured":"Lee H, Cho SMJ, Park JH, Park S, Kim HC. 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