{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:45:55Z","timestamp":1759941955385,"version":"3.41.2"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,7,4]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients after heart transplantation, systemic arterial hypertension and enhanced central aortic stiffness contribute to increased ventricular afterload, which might lead to graft dysfunction. The aim of our study was to characterize systemic arterial elastance and its impact on left ventricular function and ventriculo\u2010arterial coupling in a cohort of children, adolescents, and young adults after heart transplantation using invasive conductance catheter technique.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Thirty patients who had heart transplants (age, 20.0\u00b16.5\u2009years, 7 female) underwent invasive cardiac catheterization including pressure\u2010volume loop analysis. Load\u2010independent parameters of systolic (ventricular elastance [Ees]) and diastolic (ventricular compliance) function as well as systemic arterial elastance (Ea, end\u2010systolic pressure\/stroke volume) and ventriculo\u2010arterial coupling (Ea\/Ees) were assessed at baseline level and during dobutamine infusion (10\u2009\u03bcg\/kg\/min). Ees showed an appropriate increase under inotropic stimulation from 0.43 (0.11\u20132.52) to 1.00 (0.20\u20135.10) mm\u2009Hg\/mL\/m\n              <jats:sup>2<\/jats:sup>\n              (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), whereas ventricular compliance remained rather unchanged (0.16\u00b10.10\u2009mm\u2009Hg\/mL\/m\n              <jats:sup>2<\/jats:sup>\n              to 0.12\u00b10.07\u2009mm\u2009Hg\/mL\/m\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.10). Ventriculo\u2010arterial coupling Ea\/Ees was abnormal at rest and did not improve significantly under dobutamine (1.7 [0.6\u20136.7] to 1.3 [0.5\u20134.9],\n              <jats:italic>P<\/jats:italic>\n              =0.70) due to a simultaneous rise in Ea from 0.71 (0.37\u20132.82) to 1.10 (0.52\u20134.03) mm\u2009Hg\/mL\/m\n              <jats:sup>2<\/jats:sup>\n              (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). Both Ees and ventricular compliance were significantly associated with Ea at baseline and under dobutamine infusion.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients who underwent heart transplantation show impaired ventriculo\u2010arterial coupling at rest and under inotropic stimulation despite preserved left ventricular contractile reserve. An abnormal response in vascular function resulting in increased afterload seems to represent an important factor that may play a role for the development of late graft failure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.028766","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T10:13:08Z","timestamp":1688033588000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Left Ventricular Physiology and Ventricular\u2010Vascular Interactions in Young Patients After Heart Transplantation"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3939-6025","authenticated-orcid":false,"given":"Heiner","family":"Latus","sequence":"first","affiliation":[{"name":"Pediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany"},{"name":"Clinic for Pediatric Cardiology and Congenital Heart Disease Klinikum Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona","family":"Raap","sequence":"additional","affiliation":[{"name":"Pediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0203-2498","authenticated-orcid":false,"given":"Karin","family":"Klingel","sequence":"additional","affiliation":[{"name":"Cardiopathology Institute for Pathology and Neuropathology, University Hospital T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1010-4327","authenticated-orcid":false,"given":"Christoph","family":"Happel","sequence":"additional","affiliation":[{"name":"Pediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany"},{"name":"Department of Pediatric Cardiology Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Moysich","sequence":"additional","affiliation":[{"name":"Pediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Khalil","sequence":"additional","affiliation":[{"name":"Pediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-5612","authenticated-orcid":false,"given":"Gunter","family":"Kerst","sequence":"additional","affiliation":[{"name":"Pediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany"},{"name":"Clinic for Pediatric Cardiology and Congenital Heart Disease Klinikum Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Milla","sequence":"additional","affiliation":[{"name":"Cardiopathology Institute for Pathology and Neuropathology, University Hospital T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Skrzypek","sequence":"additional","affiliation":[{"name":"Pediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Thul","sequence":"additional","affiliation":[{"name":"Pediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Jux","sequence":"additional","affiliation":[{"name":"Pediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4559-9021","authenticated-orcid":false,"given":"Dietmar","family":"Schranz","sequence":"additional","affiliation":[{"name":"Pediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6780-8077","authenticated-orcid":false,"given":"Christian","family":"Apitz","sequence":"additional","affiliation":[{"name":"Pediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany"},{"name":"Department of Pediatric Cardiology University Children\u2019s Hospital Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.08.005"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-021-00803-7"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002738"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000769"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.001"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.11.007"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2004.05.032"},{"key":"e_1_3_1_9_2","first-page":"1109","article-title":"Occult restrictive hemodynamics after pediatric heart transplantation","volume":"14","author":"Pahl E","year":"1995","unstructured":"Pahl E, Miller SA, Griffith BP, Fricker FJ. Occult restrictive hemodynamics after pediatric heart transplantation. J Heart Lung Transplant. 1995;14:1109\u20131115.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.085"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126707"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2009.09.007"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199702000-00016"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.05.017"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.063"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.11.453"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.56.4.586"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199708270-00013"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.03.065"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.10.073"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.11.002"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.07.011"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00760.2011"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.027"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.10.012"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-007-9188-6"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12250"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.09.012"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1758-7"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf02524797"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.029"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.084"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0326-x"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.028766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:29:23Z","timestamp":1715603363000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.028766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,4]]},"references-count":32,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2023,7,4]]}},"alternative-id":["10.1161\/JAHA.122.028766"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.028766","relation":{},"ISSN":["2047-9980"],"issn-type":[{"type":"electronic","value":"2047-9980"}],"subject":[],"published":{"date-parts":[[2023,7,4]]},"assertion":[{"value":"2023-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e028766"}}