{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:34:27Z","timestamp":1792586067459,"version":"4.5.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,7,4]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Population growth, aging, and major alterations in epidemiologic trends inadvertently modulate the status of rheumatic heart disease (RHD) epidemiology. This investigation predicted RHD burden pattern and temporal trends to provide epidemiologic evidence.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Prevalence, mortality, and disability\u2010adjusted life\u2010years data for RHD were obtained from the GBD (Global Burden of Disease) study. We performed decomposition analysis and frontier analysis to assess variations and burden in RHD from 1990 to 2019. In 2019, there were &gt;40.50\u2009million RHD cases worldwide, along with nearly 0.31\u2009million RHD\u2010related deaths and 10.67\u2009million years of healthy life lost to RHD. The RHD burden was commonly concentrated within lower sociodemographic index regions and countries. RHD primarily affects women (22.52\u2009million cases in 2019), and the largest age\u2010specific prevalence rate was at 25 to 29\u2009years in women and 20 to 24\u2009years in men. Multiple reports demonstrated prominent downregulation of RHD\u2010related mortality and disability\u2010adjusted life\u2010years at the global, regional, and national levels. Decomposition analysis revealed that the observed improvements in RHD burden were primarily due to epidemiological alteration; however, it was negatively affected by population growth and aging. Frontier analysis revealed that the age\u2010standardized prevalence rates were negatively linked to sociodemographic index, whereas Somalia and Burkina Faso, with lower sociodemographic index, showed the lowest overall difference from the frontier boundaries of mortality and disability\u2010adjusted life\u2010years.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">RHD remains a major global public health issue. Countries such as Somalia and Burkina Faso are particularly successful in managing adverse outcomes from RHD and may serve as a template for other countries.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.028921","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T09:35:24Z","timestamp":1687858524000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Global, Regional, and National Advances Toward the Management of Rheumatic Heart Disease Based on the Global Burden of Disease Study 2019"],"prefix":"10.1161","volume":"12","author":[{"given":"Renjie","family":"Ruan","sequence":"first","affiliation":[{"name":"Department of Cardiology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou City Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department 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