{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:53:49Z","timestamp":1789541629163,"version":"build-2803163510"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,7,4]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Data on the incidence of arrhythmias, associated cardiac interventions, and outcome in patients with dextro\u2010transposition of the great arteries and atrial switch are scarce.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this multicenter analysis, we included adult patients with dextro\u2010transposition of the great arteries and atrial switch regularly followed up at 3 Swiss tertiary care hospitals. The primary outcome was a composite of left ventricular assist device, heart transplantation, and death. The secondary outcome was occurrence of ventricular tachycardia, ventricular fibrillation, or sudden cardiac death. We identified 207 patients (34% women; median age at last follow\u2010up, 35\u2009years) with dextro\u2010transposition of the great arteries and atrial switch. Arrhythmias occurred in 97 patients (47%) at a median age of 22\u2009years. A pacemaker or an implantable cardioverter\u2010defibrillator was implanted in 39 (19%) and 13 (6%) patients, respectively, and 33 (16%) patients underwent a total of 51 ablation procedures to target 60 intra\u2010atrial re\u2010entry tachycardias, 4 atrioventricular nodal re\u2010entry tachycardias, and 1 atrial fibrillation. The primary outcome occurred in 21 patients (10%), and the secondary outcome occurred in 18 patients (9%); both were more common in patients with concomitant ventricular septum defect than in those without (hazard ratio [HR], 3.06 [95% CI, 1.29\u20137.27],\n              <jats:italic>P<\/jats:italic>\n              =0.011; and HR, 3.62 [95% CI, 1.43\u20139.18],\n              <jats:italic>P<\/jats:italic>\n              =0.007, respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with dextro\u2010transposition of the great arteries and atrial switch reaching adulthood, arrhythmias occur in almost half of patients, and associated rhythm interventions are frequent. One\u2010tenth of those patients do not survive until the age of 35\u2009years free from left ventricular assist device or heart transplantation, and the outcome is worse in patients with concomitant ventricular septum defect.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.028956","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T12:32:18Z","timestamp":1687437138000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Arrhythmias and Clinical Outcomes in a Swiss Multicenter Cohort of Patients With Dextro\u2010Transposition of the Great Arteries and Atrial Switch"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9686-8928","authenticated-orcid":false,"given":"Nikolas","family":"Nozica","sequence":"first","affiliation":[{"name":"Department of Cardiology, Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0050-5717","authenticated-orcid":false,"given":"Babken","family":"Asatryan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Aur","sequence":"additional","affiliation":[{"name":"Department of Cardiology Centre Hospitalier Universitaire Vaudois University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0149-288X","authenticated-orcid":false,"given":"Judith Bouchardy","family":"Clement","sequence":"additional","affiliation":[{"name":"Department of Cardiology Centre Hospitalier Universitaire Vaudois University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-8929","authenticated-orcid":false,"given":"Markus","family":"Schwerzmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1832-4201","authenticated-orcid":false,"given":"Fu","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zurich University Hospital University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7328-2481","authenticated-orcid":false,"given":"Patrizio","family":"Pascale","sequence":"additional","affiliation":[{"name":"Department of Cardiology Centre Hospitalier Universitaire Vaudois University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-1745","authenticated-orcid":false,"given":"Matthias","family":"Gass","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zurich University Hospital University of Zurich Zurich Switzerland"},{"name":"Department of Cardiology University Children\u2019s Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4748-0158","authenticated-orcid":false,"given":"Firat","family":"Duru","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zurich University Hospital University of Zurich Zurich Switzerland"},{"name":"Center for Integrative Human Physiology University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-8415","authenticated-orcid":false,"given":"Tobias","family":"Reichlin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1386-9285","authenticated-orcid":false,"given":"Etienne","family":"Pruvot","sequence":"additional","affiliation":[{"name":"Department of Cardiology Centre Hospitalier Universitaire Vaudois University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9143-5530","authenticated-orcid":false,"given":"Thomas","family":"Wolber","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zurich University Hospital University of Zurich Zurich Switzerland"},{"name":"Center for Integrative Human Physiology University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0827-1329","authenticated-orcid":false,"given":"Laurent","family":"Roten","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","article-title":"Challenges of congenital heart disease in grown\u2010up patients","volume":"147","author":"Schwerzmann M","year":"2017","unstructured":"Schwerzmann M, Schwitz F, Thomet C, Kadner A, Pfammatter J\u2010P, Wustmann K. Challenges of congenital heart disease in grown\u2010up patients. Swiss Med Wkly. 2017;147:w14495. doi: 10.4414\/smw.2017.14495","journal-title":"Swiss Med Wkly"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.09.002"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.946343"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.592352"},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","unstructured":"Bushman GA. Transposition of the great arteries. Congenital Heart Disease in Pediatric and Adult Patients: Anesthetic and Perioperative Management Vol. 64. 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