{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:44:29Z","timestamp":1790790269229,"version":"4.1.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Transthyretin amyloid cardiomyopathy (ATTR\u2010CM) is an underdiagnosed cause of heart failure (HF) among patients \u226560\u2009years of age. Although the V122I (valine to isoleucine substitution at position 122 of the transthyretin protein) variant associated with hereditary ATTR\u2010CM is present in 3.4% of self\u2010identified Black individuals in the United States (or 1.5\u2009million people), the phenotypic penetrance is not known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The SCAN\u2010MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) study is a currently accruing prospective multisite study designed to determine the prevalence of ATTR\u2010CM using technetium\u201099m\u2010pyrophosphate imaging in older (\u226560\u2009years of age) self\u2010identified Black and Hispanic individuals with HF. Calculations of the penetrance and prevalence of the V122I allele, along with analyses of functional, biochemical, and echocardiographic parameters, were performed for the first 278 Black participants in SCAN\u2010MP. The prevalence of ATTR\u2010CM was 6.8% (95% CI, 4.2\u201310.5; n=19 cases), of whom 63% were ATTR wild\u2010type. The prevalence of V122I was 6.5% (n=18 carriers), of whom 7 had ATTR\u2010CM, yielding a phenotypic penetrance of 39% (95% CI, 17\u201364). V122I carriers with ATTR\u2010CM evidenced more advanced HF than carriers without ATTR\u2010CM. Prealbumin concentration was lowest among V122I carriers with ATTR\u2010CM (12.9\u2009mg\/dL) versus carriers without ATTR\u2010CM (21.0\u2009mg\/dL) and HF controls (25.0\u2009mg\/dL,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among older Black individuals with HF and increased left ventricular wall thickness, of those with ATTR\u2010CM, 63% had wild\u2010type, and of those with V122I, the phenotypic penetrance of ATTR\u2010CM was 39% (95% CI, 17\u201364), suggesting that genotype alone is insufficient for diagnosis. Prealbumin concentration may be useful to identify V122I carriers with ATTR\u2010CM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT03812172.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.122.028973","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T08:22:43Z","timestamp":1690186963000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Clinical Penetrance of the Transthyretin V122I Variant in Older Black Patients With Heart Failure: The SCAN\u2010MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5747-6948","authenticated-orcid":false,"given":"Avni","family":"Madhani","sequence":"first","affiliation":[{"name":"Boston University Chobanian &amp; Avedisian School of Medicine Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9107-4495","authenticated-orcid":false,"given":"Natalia","family":"Sabogal","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Medicine Boston University Chobanian &amp; Avedisian School of Medicine, Boston Medical Center Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4412-1652","authenticated-orcid":false,"given":"Daniel","family":"Massillon","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Medicine Boston University Chobanian &amp; Avedisian School of Medicine, Boston Medical Center Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7431-5924","authenticated-orcid":false,"given":"Ludwine D.","family":"Paul","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Medicine Boston University Chobanian &amp; Avedisian School of Medicine, Boston Medical Center Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Seymour, Paul, and Gloria Milstein Division of Cardiology, Department of Medicine Columbia University Irving Medical Center, and New York\u2010Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0457-6777","authenticated-orcid":false,"given":"Denise","family":"Fine","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Medicine Boston University Chobanian &amp; Avedisian School of Medicine, Boston Medical Center Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-3009","authenticated-orcid":false,"given":"Stephen","family":"Helmke","sequence":"additional","affiliation":[{"name":"Seymour, Paul, and Gloria Milstein Division of Cardiology, Department of Medicine Columbia University Irving Medical Center, and New York\u2010Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7196-209X","authenticated-orcid":false,"given":"Morgan","family":"Winburn","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Medicine Boston University Chobanian &amp; Avedisian School of Medicine, Boston Medical Center Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6470-6807","authenticated-orcid":false,"given":"Damian","family":"Kurian","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Harlem Hospital Center New York City Health and Hospital Corporation New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farbod","family":"Raiszadeh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Harlem Hospital Center New York City Health and Hospital Corporation New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Teruya","sequence":"additional","affiliation":[{"name":"Seymour, Paul, and Gloria Milstein Division of Cardiology, Department of Medicine Columbia University Irving Medical Center, and New York\u2010Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Cohn","sequence":"additional","affiliation":[{"name":"Hunter College, City University of New York New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2583-9278","authenticated-orcid":false,"given":"Andrew J.","family":"Einstein","sequence":"additional","affiliation":[{"name":"Seymour, Paul, and Gloria Milstein Division of Cardiology, Department of Medicine Columbia University Irving Medical Center, and New York\u2010Presbyterian Hospital New York NY"},{"name":"Department of Radiology Columbia University Irving Medical Center, and New York\u2010Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2156-5962","authenticated-orcid":false,"given":"Edward J.","family":"Miller","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Medicine Yale School of Medicine New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawreen H.","family":"Connors","sequence":"additional","affiliation":[{"name":"Amyloidosis Center Boston University Chobanian &amp; 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