{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:29:33Z","timestamp":1770895773344,"version":"3.50.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The benefits of long\u2010term maintenance beta\u2010blocker (BB) therapy in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) have not been well established.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Using the Korean nationwide registry, a total of 7159 patients with AMI treated with PCI who received BBs at discharge and were free from death or cardiovascular events for 3\u2009months after PCI were included in the analysis. Patients were divided into 4 groups according to BB maintenance duration: &lt;12\u2009months, 12 to &lt;24\u2009months, 24 to &lt;36\u2009months, and \u226536\u2009months. The primary outcome was the composite of all\u2010cause death, recurrent MI, heart failure, or hospitalization for unstable angina. During a mean 5.0\u00b12.8\u2009years of follow\u2010up, over half of patients with AMI (52.5%) continued BB therapy beyond 3\u2009years following PCI. After propensity score matching and propensity score marginal mean weighting through stratification, a stepwise inverse correlation was noted between BB duration and risk of the primary outcome (&lt;12\u2009months: hazard ratio [HR], 2.19 [95% CI, 1.95\u20132.46]; 12 to &lt;24\u2009months: HR, 2.10 [95% CI, 1.81\u20132.43];, and 24 to &lt;36\u2009months: HR, 1.68 [95%CI, 1.45\u20131.94]; reference: \u226536\u2009months). In a 3\u2010year landmark analysis, BB use for &lt;36\u2009months was associated with an increased risk of the primary outcome (adjusted HR, 1.59 [95% CI, 1.37\u20131.85]) compared with BB use for \u226536\u2009months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among stabilized patients with AMI following PCI, longer maintenance BB therapy, especially for &gt;36\u2009months, was associated with better clinical outcomes. These findings might imply that a better prognosis can be expected if patients with AMI maintain BB therapy for \u226536\u2009months after PCI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT02806102.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.028976","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T09:35:06Z","timestamp":1690364106000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative Effectiveness of Long\u2010Term Maintenance Beta\u2010Blocker Therapy After Acute Myocardial Infarction in Stable, Optimally Treated Patients Undergoing Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0658-4081","authenticated-orcid":false,"given":"Myunhee","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Cardiology, Daejeon St. Mary\u2019s Hospital, College of Medicine The Catholic University of Korea Seoul Republic of Korea"},{"name":"Catholic Research Institute for Intractable Cardiovascular Disease CRID, College of Medicine The Catholic University of Korea Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0149-5503","authenticated-orcid":false,"given":"Kyusup","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Daejeon St. Mary\u2019s Hospital, College of Medicine The Catholic University of Korea Seoul Republic of Korea"},{"name":"Catholic Research Institute for 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The Catholic University of Korea Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4230-7698","authenticated-orcid":false,"given":"Tae\u2010Seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Daejeon St. Mary\u2019s Hospital, College of Medicine The Catholic University of Korea Seoul Republic of Korea"},{"name":"Catholic Research Institute for Intractable Cardiovascular Disease CRID, College of Medicine The Catholic University of Korea Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jongbum","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Daejeon St. Mary\u2019s Hospital The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2929-8325","authenticated-orcid":false,"given":"Chan 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Yeol","family":"Kim","sequence":"additional","affiliation":[{"name":"Catholic Research Institute for Intractable Cardiovascular Disease CRID, College of Medicine The Catholic University of Korea Seoul South Korea"},{"name":"Division of Cardiology, Department of Internal Medicine, Bucheon St. Mary\u2019s Hospital The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5425-1102","authenticated-orcid":false,"given":"Ki\u2010Dong","family":"Yoo","sequence":"additional","affiliation":[{"name":"Catholic Research Institute for Intractable Cardiovascular Disease CRID, College of Medicine The Catholic University of Korea Seoul South Korea"},{"name":"Division of Cardiology, Department of Internal Medicine, St. Vincent\u2019s Hospital The Catholic University of Korea Seoul Republic of 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