{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:10:17Z","timestamp":1788959417075,"version":"build-2803163510"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,4,4]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Racial and ethnic disparities in outcomes exist following many cardiac procedures. Transcatheter mitral valve replacement (TMVR) has grown as an alternative to mitral valve surgery for patients at high surgical risk. The outcomes of TMVR by race and ethnicity\u00a0are unknown. We aimed to evaluate racial\u00a0and ethnic disparities in the outcomes of TMVR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We analyzed the National Inpatient Sample database from 2016 to 2020 to identify hospitalizations for TMVR. Racial and ethnic disparities in TMVR outcomes were determined using logistic regression models. Between 2016 and 2020, 5005 hospitalizations for TMVR were identified, composed of 3840 (76.7%) White race, 505 (10.1%) Black race, 315 (6.3%) Hispanic ethnicity, and 345 (6.9%) from other races (Asian, Pacific Islander, American Indian or Alaska Native, Other). Compared with other racial and ethnic groups, Black patients were significantly younger and more likely to be women (both\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). There were no significant differences between White, Black, and Hispanic patients in in\u2010hospital mortality (5.2% versus 5.0% versus &lt;3.5%;\n              <jats:italic>P<\/jats:italic>\n              =0.89) and procedural complications, including heart block (\n              <jats:italic>P<\/jats:italic>\n              =0.91), permanent pacemaker (\n              <jats:italic>P<\/jats:italic>\n              =0.49), prosthetic valve dysfunction (\n              <jats:italic>P<\/jats:italic>\n              =0.45), stroke (\n              <jats:italic>P<\/jats:italic>\n              =0.37), acute kidney injury (\n              <jats:italic>P<\/jats:italic>\n              =0.32), major bleeding (\n              <jats:italic>P<\/jats:italic>\n              =0.23), and blood transfusion (\n              <jats:italic>P<\/jats:italic>\n              =0.92), even after adjustment for baseline characteristics. Adjusted vascular complications were higher in Black compared with White patients (\n              <jats:italic>P<\/jats:italic>\n              =0.03). Trend analysis revealed a significant increase in TMVR in all racial and ethnic groups from 2016 to 2020 (\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              &lt;0.05).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Between 2016 and 2020, Black and Hispanic patients undergoing TMVR had similar in\u2010hospital outcomes compared with White patients, except for higher vascular complications in Black patients. Further comparative studies of TMVR in clinically similar White patients and other racial and ethnic\u00a0groups are warranted to confirm our findings.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.028999","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T09:21:04Z","timestamp":1679995264000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Racial and Ethnic Disparities in the Use and Outcomes of Transcatheter Mitral Valve Replacement: Analysis From the National Inpatient Sample Database"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9033-7835","authenticated-orcid":false,"given":"Mahmoud","family":"Ismayl","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Creighton University School of Medicine Omaha NE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhannad Aboud","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9025-7453","authenticated-orcid":false,"given":"Abdullah","family":"Al\u2010Abcha","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"El\u2010Am","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8801-9886","authenticated-orcid":false,"given":"Ryan W.","family":"Walters","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Evaluative Sciences Creighton University School of Medicine Omaha NE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2952-7837","authenticated-orcid":false,"given":"Andrew M.","family":"Goldsweig","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Baystate Medical Center Springfield MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-0959","authenticated-orcid":false,"given":"Mohamad","family":"Alkhouli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-8096","authenticated-orcid":false,"given":"Mayra","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandan S.","family":"Anavekar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000932"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-307020"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.08.723"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.001943"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.001607"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.10.043"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2018.10.021"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.4041"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.05.030"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000157737.92938.D8"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1532\/HSF98.20101124"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27257"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.03.007"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2020.04.034"},{"key":"e_1_3_1_18_2","unstructured":"Overview of the National (Nationwide) Inpatient Sample. 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