{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:24:12Z","timestamp":1791483852020,"version":"4.3.4"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,4,4]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Right heart catheterization (RHC) is a high\u2010risk procedure in children with pulmonary arterial hypertension without clear guidelines for the indications and targets of invasive reassessment. Our objectives are to define the aims of repeated RHC and evaluate the correlation between noninvasive criteria and hemodynamic parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Clinical and hemodynamic characteristics from 71 incident treatment\u2010na\u00efve children (median age 6.2\u2009years) with pulmonary arterial hypertension who had a baseline and reevaluation RHC were analyzed. Correlations between noninvasive predictors and hemodynamic parameters were tested. Adverse outcomes were defined as death, lung transplantation, or Potts shunt. At baseline, pulmonary vascular resistance index (hazard ratio [HR] 1.07 per 1 WU\u00b7m\n                      <jats:sup>2<\/jats:sup>\n                      increase [95% CI, 1.02\u20131.12],\n                      <jats:italic>P<\/jats:italic>\n                      =0.002), stroke volume index (HR 0.95 per 1 L\u00b7min\n                      <jats:sup>\u22121<\/jats:sup>\n                      \u00b7m\n                      <jats:sup>\u22122<\/jats:sup>\n                      increase [95% CI, 0.91\u20130.99],\n                      <jats:italic>P<\/jats:italic>\n                      =0.012), pulmonary artery compliance index (HR 0.16 per 1\u2009mL\u00b7mm\u2009Hg\n                      <jats:sup>\u22121\u00b7<\/jats:sup>\n                      m\n                      <jats:sup>\u22122<\/jats:sup>\n                      increase [95% CI, 0.051\u20130.52],\n                      <jats:italic>P<\/jats:italic>\n                      =0.002), and right atrial pressure (HR, 1.31 per 1\u2009mm\u2009Hg increase [95% CI, 1.01\u20131.71],\n                      <jats:italic>P<\/jats:italic>\n                      =0.043) were associated with adverse outcomes. Pulmonary vascular resistance index, pulmonary artery compliance index, and right atrial pressure were still associated with a worse outcome at second RHC. Noninvasive criteria accurately predicted hemodynamic evolution; however, 70% of the patients who had improved based on noninvasive criteria still presented at least 1 \u201cat risk\u201d hemodynamics at second RHC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Pulmonary vascular resistance index, pulmonary artery compliance index, and right atrial pressure are solid predictors of adverse outcomes in pediatric pulmonary arterial hypertension and potential therapeutic targets. Noninvasive criteria accurately predict the evolution of hemodynamic parameters, but insufficiently. Repeated RHC are helpful to identify children with persistent higher risk after treatment introduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.122.029085","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T05:23:12Z","timestamp":1679980992000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Monitoring of Hemodynamics With Right Heart Catheterization in Children With Pulmonary Arterial Hypertension"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5593-3383","authenticated-orcid":false,"given":"Julien","family":"Grynblat","sequence":"first","affiliation":[{"name":"M3C\u2010Necker, H\u00f4pital Necker\u2010Enfants malades, AP\u2010HP Universit\u00e9 de Paris Cit\u00e9, Cardiologie Cong\u00e9nitale et P\u00e9diatrique Paris France"},{"name":"Universit\u00e9 Paris\u2010Saclay, Faculty of Medicine Le Kremlin\u2010Bic\u00eatre France"},{"name":"INSERM UMR_S 999, H\u00f4pital Marie Lannelongue Le Plessis Robinson France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9527-3671","authenticated-orcid":false,"given":"Sophie\u2010Guiti","family":"Malekzadeh\u2010Milani","sequence":"additional","affiliation":[{"name":"M3C\u2010Necker, H\u00f4pital Necker\u2010Enfants malades, AP\u2010HP Universit\u00e9 de Paris Cit\u00e9, Cardiologie Cong\u00e9nitale et P\u00e9diatrique Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-5580","authenticated-orcid":false,"given":"Mathilde","family":"Meot","sequence":"additional","affiliation":[{"name":"M3C\u2010Necker, H\u00f4pital Necker\u2010Enfants malades, AP\u2010HP Universit\u00e9 de Paris Cit\u00e9, Cardiologie Cong\u00e9nitale et P\u00e9diatrique Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7730-2427","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Perros","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, Faculty of Medicine Le Kremlin\u2010Bic\u00eatre France"},{"name":"INSERM UMR_S 999, H\u00f4pital Marie Lannelongue Le Plessis Robinson France"},{"name":"Department of Respiratory and Intensive Care Medicine, AP\u2010HP H\u00f4pital Bic\u00eatre Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Szezepanski","sequence":"additional","affiliation":[{"name":"M3C\u2010Necker, H\u00f4pital Necker\u2010Enfants malades, AP\u2010HP Universit\u00e9 de Paris Cit\u00e9, Cardiologie Cong\u00e9nitale et P\u00e9diatrique Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Morisset","sequence":"additional","affiliation":[{"name":"Freelance Biostatistician P\u00e9rouges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2277-2760","authenticated-orcid":false,"given":"Caroline","family":"Ovaert","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology La Timone Hospital, CHU Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7592-8589","authenticated-orcid":false,"given":"Caroline","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology CHU Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Maragnes","sequence":"additional","affiliation":[{"name":"Department of Cardiology Caen University, CHU de CAEN Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Ranchoup","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, CHU Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-2892","authenticated-orcid":false,"given":"Marc","family":"Humbert","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, Faculty of Medicine Le Kremlin\u2010Bic\u00eatre France"},{"name":"INSERM UMR_S 999, H\u00f4pital Marie Lannelongue Le Plessis Robinson France"},{"name":"Department of Respiratory and Intensive Care Medicine, AP\u2010HP H\u00f4pital Bic\u00eatre Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-6922","authenticated-orcid":false,"given":"I. 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