{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:25:04Z","timestamp":1793816704967,"version":"4.6.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,7,4]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Severe cardiac cachexia or malnutrition are commonly considered relative contraindications to left ventricular assist device (LVAD) implantation, but post\u2010LVAD prognosis for patients with cachexia is uncertain.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Intermacs (Interagency Registry for Mechanically Assisted Circulatory Support) 2006 to 2017 was queried for the preimplantation variable cachexia\/malnutrition. Cox proportional hazards modeling examined the relationship between cachexia and LVAD outcomes. Of 20\u2009332 primary LVAD recipients with available data, 516 (2.54%) were reported to have baseline cachexia and had higher risk baseline characteristics. Cachexia was associated with higher mortality during LVAD support (unadjusted hazard ratio [HR], 1.36 [95% CI, 1.18\u20131.56];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), persisting after adjustment for baseline characteristics (adjusted HR, 1.23 [95% CI, 1.0\u20131.42];\n              <jats:italic>P<\/jats:italic>\n              =0.005). Mean weight change at 12 months was +3.9\u00b19.4\u2009kg. Across the cohort, weight gain \u22655% during the first 3 months of LVAD support was associated with lower mortality (unadjusted HR, 0.90 [95% CI, 0.84\u20130.98];\n              <jats:italic>P<\/jats:italic>\n              =0.012; adjusted HR, 0.89 [95% CI, 0.82\u20130.97];\n              <jats:italic>P<\/jats:italic>\n              =0.006).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The proportion of LVAD recipients recognized to have cachexia preimplantation was low at 2.5%. Recognized cachexia was independently associated with higher mortality during LVAD support. Early weight gain \u22655% was independently associated with lower mortality during subsequent LVAD support.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.029086","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T10:12:06Z","timestamp":1688033526000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Cardiac Cachexia in Left Ventricular Assist Device Recipients and the Implications of Weight Gain Early After Implantation"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8274-5660","authenticated-orcid":false,"given":"Amanda R.","family":"Vest","sequence":"first","affiliation":[{"name":"CardioVascular Center Tufts Medical Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0664-8978","authenticated-orcid":false,"given":"Lori 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Center Tufts Medical Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4026-6383","authenticated-orcid":false,"given":"Michael S.","family":"Kiernan","sequence":"additional","affiliation":[{"name":"CardioVascular Center Tufts Medical Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenica N.","family":"Upshaw","sequence":"additional","affiliation":[{"name":"CardioVascular Center Tufts Medical Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3580-5664","authenticated-orcid":false,"given":"Masashi","family":"Kawabori","sequence":"additional","affiliation":[{"name":"CardioVascular Center Tufts Medical Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.","family":"Couper","sequence":"additional","affiliation":[{"name":"CardioVascular Center Tufts Medical Center Boston MA 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