{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:47:25Z","timestamp":1787921245535,"version":"build-2784847793"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,7,18]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Little is known regarding the impact of donor COVID\u201019 status on recipient outcomes after heart transplantation. In this study, we characterize outcomes of the first 110 heart transplants from organ donors positive for COVID\u201019 (COVID\u201019+) in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Retrospective analysis of the United Network for Organ Sharing database was performed for single\u2010organ adult heart transplants from January 2020 to March 2022. Donor COVID\u201019+ status was defined as a positive nucleic acid amplification, antigen, or other COVID\u201019 test within 7\u2009days of transplant. Nearest\u2010neighbor propensity score matching used to adjust for differences between recipients of COVID\u201019+ and nonpositive donor hearts. Overall, 7251 heart transplants were included in analysis, with 110 using COVID\u201019+ donor hearts. Recipients of COVID\u201019+ allografts were younger (54 [interquartile range, 41\u201361]) versus 57 [46\u201364] years;\n                      <jats:italic>P<\/jats:italic>\n                      =0.02) but had similar rates of female sex and non\u2010White race compared with those receiving allografts from negative donors. Nearest\u2010neighbor propensity score matching resulted in 100 well\u2010matched pairs of recipients of COVID\u201019+ versus nonpositive donor organs. The 2 matched groups had similar median lengths of stay (15 [11\u201323] days versus 15 [13\u201323] days;\n                      <jats:italic>P<\/jats:italic>\n                      =0.40), rates of graft failure (1% versus 0%;\n                      <jats:italic>P<\/jats:italic>\n                      =0.99), 30\u2010day death (3% versus 3%;\n                      <jats:italic>P<\/jats:italic>\n                      =0.99), and 3\u2010month survival (88% versus 94%;\n                      <jats:italic>P<\/jats:italic>\n                      =0.23) compared with recipients of nonpositive donors. No deaths occurred due to COVID\u201019 infection among the 8 (7%) total deceased recipients of COVID\u201019+ allografts to date.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Short\u2010term outcomes of heart transplant recipients receiving COVID\u201019+ donor organs are reassuring. However, continued monitoring for long\u2010term survival and potential complications are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.122.029178","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T07:24:37Z","timestamp":1688801077000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Outcomes of COVID\u201019\u2013Positive Donor Heart Transplantation in the United States"],"prefix":"10.1161","volume":"12","author":[{"given":"Samuel T.","family":"Kim","sequence":"first","affiliation":[{"name":"David Geffen School of Medicine University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7689-1733","authenticated-orcid":false,"given":"Amit","family":"Iyengar","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Helmers","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3813-7355","authenticated-orcid":false,"given":"Noah","family":"Weingarten","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7169-8950","authenticated-orcid":false,"given":"David","family":"Rekhtman","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-6085","authenticated-orcid":false,"given":"Cindy","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2748-3052","authenticated-orcid":false,"given":"Max","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Cevasco","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0229-085X","authenticated-orcid":false,"given":"Pavan","family":"Atluri","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","unstructured":"COVID\u201019 (Coronavirus): FAQs for organ transplantation. American Society of Transplantation. Published February 1 2023. Accessed March 1 2023. https:\/\/www.myast.org\/covid\u201019\u2010information."},{"key":"e_1_3_1_3_2","unstructured":"Organ retrieval for transplantation in the COVID\u201019 era. American Society of Transplant Surgeons. Published March 27 2020. Accessed August 1 2020. https:\/\/asts.org\/advocacy\/covid\u201019\u2010resources\/asts\u2010covid\u201019\u2010strike\u2010force\/asts\u2010covid\u201019\u2010strike\u2010force\u2010organ\u2010retrieval\u2010guidance#.YzT8rC2B1QI."},{"key":"e_1_3_1_4_2","unstructured":"Guidance from the International Society of Heart and Lung Transplantation regarding the SARS CoV\u20102 pandemic. The International Society of Heart and Lung Transplantation. Published February 1 2021. Accessed August 1 2022. https:\/\/ishlt.org\/ishlt\/media\/documents\/SARS\u2010CoV\u20102_Guidance\u2010for\u2010Cardiothoracic\u2010Transplant\u2010and\u2010VAD\u2010center.pdf."},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1097"},{"key":"e_1_3_1_6_2","unstructured":"Lin S Rakita R Limaye A. Heart transplantation with COVID\u201019 positive donors. American College of Cardiology. Published May 10 2022. Accessed August 1 2022. https:\/\/www.acc.org\/Latest\u2010in\u2010Cardiology\/Articles\/2022\/05\/10\/12\/02\/Heart\u2010Transplantation\u2010With\u2010COVID\u201019\u2010Positive\u2010Donors"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.06.018"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16823"},{"key":"e_1_3_1_9_2","unstructured":"2112 Public Standard Analysis Files Data Dictionary. Scientific Registry of Transplant Recipients. Published June 1 2022. 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United Network for Organ Sharing Database. Published April 27 2022. Accessed December 1 2022. https:\/\/unos.org\/news\/optn\u2010death\u2010verification\u2010updated\u2010numbers\u2010april\u20102022\/."},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12777"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001387"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.029178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:24:22Z","timestamp":1715588662000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.029178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,18]]},"references-count":32,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2023,7,18]]}},"alternative-id":["10.1161\/JAHA.122.029178"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.029178","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,18]]},"assertion":[{"value":"2022-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e029178"}}