{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:17:51Z","timestamp":1787887071855,"version":"build-2784847793"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,5,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">A previous coronary computed tomography (CT) angiographic study failed to discriminate optical coherence tomography\u2010defined intact fibrous cap culprit lesions (IFC group) from those with ruptured fibrous caps (RFC group) in patients with coronary artery disease. This study aimed to evaluate the diagnostic efficacy of preprocedural coronary CT imaging in identifying subsequently performed optical coherence tomography\u2010defined plaque rupture or erosion at culprit lesions in patients with non\u2013ST\u2010segment\u2013elevation acute myocardial infarction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This study used data from 2 recently published studies that tested the hypothesis that coronary CT angiography (CCTA) before percutaneous coronary intervention may provide diagnostic information on the high\u2010risk atherosclerotic burden in patients with non\u2013ST\u2010segment\u2013elevation acute myocardial infarction. In the analysis of 186 patients, optical coherence tomography identified 106 RFC plaques and 80 IFC plaques as the culprit lesions. On CT, the prevalence of low\u2010attenuation plaque, positive remodeling, napkin\u2010ring sign, and spotty calcification were all significantly lower in the IFC group. The culprit vessel pericoronary adipose tissue inflammation and coronary artery calcium scores were significantly lower in the IFC group than in the RFC group. The absence of low\u2010attenuation plaque, napkin\u2010ring sign, zero coronary artery calcium, and low pericoronary adipose tissue inflammation were independent predictors of IFC. When stratified into 5 subgroups according to the number of these 4 CT factors, the prevalence of IFC was 8.3%, 20.8%, 44.6%, 75.6%, and 100% (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Preprocedural comprehensive coronary CT imaging, including coronary artery calcium and pericoronary adipose tissue inflammation assessment, can accurately and noninvasively identify optical coherence tomography\u2010defined IFC or RFC culprit lesions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.029239","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:13:16Z","timestamp":1684145596000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Identification of Optical Coherence Tomography\u2010Defined Coronary Plaque Erosion by Preprocedural Computed Tomography Angiography"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6242-849X","authenticated-orcid":false,"given":"Tatsuhiro","family":"Nagamine","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3661-1914","authenticated-orcid":false,"given":"Masahiro","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1798-5008","authenticated-orcid":false,"given":"Taishi","family":"Yonetsu","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Tokyo Medical and Dental University 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