{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:00:37Z","timestamp":1787871637119,"version":"build-2784847793"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Acute type B aortic dissection is a cardiovascular emergency with considerable mortality and morbidity risk. Male\u2013female differences have been observed in cardiovascular disease; however, literature on type B aortic dissection is scarce.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A retrospective cohort study was conducted including all consecutive patients with acute type B aortic dissection between 2007 and 2017 in 4 tertiary hospitals using patient files and questionnaires for late morbidity. In total, 384 patients were included with a follow\u2010up of 6.1 (range, 0.02\u201314.8) years, of which 41% (n=156) were female. Women presented at an older age than men (67 [interquartile range (IQR), 57\u201373] versus 62 [IQR, 52\u201371];\n              <jats:italic>P<\/jats:italic>\n              =0.015). Prior abdominal aortic aneurysm (6% versus 15%;\n              <jats:italic>P<\/jats:italic>\n              =0.009), distally extending dissections (71 versus 85%;\n              <jats:italic>P<\/jats:italic>\n              =0.001), and clinical malperfusion (18% versus 32%;\n              <jats:italic>P<\/jats:italic>\n              =0.002) were less frequently observed in women. Absolute maximal descending aortic diameters were smaller in women (36 [IQR: 33\u201340] mm versus 39 [IQR, 36\u201343] mm;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), while indexed for body surface area diameters were larger in women (20 [IQR, 18\u201323] mm\/m\n              <jats:sup>2<\/jats:sup>\n              versus 19 [IQR, 17\u201321] mm\/m\n              <jats:sup>2<\/jats:sup>\n              ). No male\u2013female differences were found in treatment choice; however, indications for invasive treatment were different (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Early mortality rate was 9.6% in women and 11.8% in men (\n              <jats:italic>P<\/jats:italic>\n              =0.60). The 5\u2010year survival was 83% (95% CI, 77\u201389) for women and 84% (95% CI, 79\u201389) for men (\n              <jats:italic>P<\/jats:italic>\n              =0.90). No male\u2013female differences were observed in late (re)interventions.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">No male\u2013female differences were found in management, early or late death, and morbidity in patients presenting with acute type B aortic dissection, despite distinct clinical profiles at presentation. More details on the impact of age and type of intervention are warranted in future studies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.029258","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T10:51:56Z","timestamp":1703847116000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Male\u2013Female Differences in Acute Type B Aortic Dissection"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3244-8195","authenticated-orcid":false,"given":"Frederike","family":"Meccanici","sequence":"first","affiliation":[{"name":"Department of Cardiology Erasmus University Medical Center Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlijn G. E.","family":"Thijssen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus University Medical Center Rotterdam Netherlands"},{"name":"Department of Cardiology Radboud University Medical Center Nijmegen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin H.","family":"Heijmen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery St. Antonius Hospital Nieuwegein Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0407-2901","authenticated-orcid":false,"given":"Guillaume S. C.","family":"Geuzebroek","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Radboud University Medical Center Nijmegen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1886-4045","authenticated-orcid":false,"given":"Joost F.","family":"ter Woorst","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Catharina Hospital Eindhoven Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8126-6844","authenticated-orcid":false,"given":"Arjen L.","family":"G\u00f6kalp","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Erasmus University Medical Center Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorg L.","family":"de Bruin","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Erasmus University Medical Center Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daantje N.","family":"Gratama","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Erasmus University Medical Center Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos A.","family":"Bekkers","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Erasmus University Medical Center Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland R. J.","family":"van Kimmenade","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus University Medical Center Rotterdam Netherlands"},{"name":"Department of Cardiology Radboud University Medical Center Nijmegen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Poyck","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Radboud University Medical Center Nijmegen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-9491","authenticated-orcid":false,"given":"Kathinka","family":"Peels","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco C.","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein Netherlands"},{"name":"Department of Cardiology University Medical Center Utrecht Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa M.","family":"Mokhles","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Erasmus University Medical Center Rotterdam Netherlands"},{"name":"Department of Cardiothoracic Surgery University Medical Center Utrecht Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9809-5623","authenticated-orcid":false,"given":"Johanna J. 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