{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T20:02:01Z","timestamp":1787688121096,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,8,15]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There is uncertainty about the appropriate use of primary prevention implantable cardioverter\u2010defibrillators (ICDs) among older patients with hypertrophic cardiomyopathy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients with hypertrophic cardiomyopathy who received a primary prevention ICD between 2010 and 2016 were identified using the National Cardiovascular Data Registry ICD Registry. Trends in ICD utilization and patient characteristics were assessed over time. Using linked Centers for Medicare and Medicaid Service claims data, Cox proportional hazard models assessed factors associated with mortality and postdischarge hospitalization for cardiac arrest\/ventricular arrhythmia. Of 5571 patients with hypertrophic cardiomyopathy, 1511 (27.1%) were \u226565\u2009years old. ICD utilization increased over time in all age groups. There were no changes in the prevalence of risk factors for sudden cardiac death over time. The variables most strongly associated with postdischarge mortality were older age (adjusted hazard ratio (aHR) 1.80 [95% CI, 1.47\u20132.21]), New York Heart Association class (III\/IV versus I\/II aHR 2.17 [95% CI, 1.57\u20132.98]), and left ventricular ejection fraction (left ventricular ejection fraction \u226435% versus &gt;50% aHR 2.34 [95% CI, 1.58\u20133.48]; left ventricular ejection fraction 36%\u201350% versus &gt;50% aHR 2.98 [95% CI, 2.02\u20134.40]), while history of nonsustained ventricular tachycardia (aHR 2.38 [95% CI, 1.62\u20133.51]) and New York Heart Association class (III\/IV versus I\/II aHR 1.84 [95% CI, 1.22\u20132.78]) were strongly associated with hospitalization for ventricular arrhythmia\/cardiac arrest.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Primary prevention ICD utilization in patients with hypertrophic cardiomyopathy increased over time, including among those \u226565\u2009years old. Among older patients, the strongest risk factors for hospitalization for ventricular arrhythmia\/cardiac arrest following ICD implantation were history of nonsustained ventricular tachycardia and New York Heart Association class.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.029293","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T10:30:15Z","timestamp":1691663415000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Utilization and Outcomes of Primary Prevention Implantable Cardioverter\u2010Defibrillators in Patients With Hypertrophic Cardiomyopathy"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7789-4773","authenticated-orcid":false,"given":"Sarah A.","family":"Goldstein","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin F.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5791-1954","authenticated-orcid":false,"given":"Daniel J.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Duke University Medical Center Durham NC USA"},{"name":"Duke Clinical Research Institute Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3561-0146","authenticated-orcid":false,"given":"Sana M.","family":"Al\u2010Khatib","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Duke University Medical Center Durham NC USA"},{"name":"Duke Clinical Research Institute Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8729-0933","authenticated-orcid":false,"given":"Andrew","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Duke University Medical Center Durham NC 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