{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:43:26Z","timestamp":1793202206005,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,7,18]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">To study the prevalence and types of hypertension\u2010mediated organ damage and the prognosis of patients presenting to the emergency department (ED) with hypertensive emergencies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">PubMed was queried from inception through November 30, 2021. Studies were included if they reported the prevalence or prognosis of hypertensive emergencies in patients presenting to the ED. Studies reporting data on hypertensive emergencies in other departments were excluded. The extracted data were arcsine transformed and pooled using a random\u2010effects model. Fifteen studies (n=4370 patients) were included. Pooled analysis demonstrates that the prevalence of hypertensive emergencies was 0.5% (95% CI, 0.40%\u20130.70%) in all patients presenting to ED and 35.9% (95% CI, 26.7%\u201345.5%) among patients presenting in ED with hypertensive crisis. Ischemic stroke (28.1% [95% CI, 18.7%\u201338.6%]) was the most prevalent hypertension\u2010mediated organ damage, followed by pulmonary edema\/acute heart failure (24.1% [95% CI, 19.0%\u201329.7%]), hemorrhagic stroke (14.6% [95% CI, 9.9%\u201320.0%]), acute coronary syndrome (10.8% [95% CI, 7.3%\u201314.8%]), renal failure (8.0% [95% CI, 2.9%\u201315.5%]), subarachnoid hemorrhage (6.9% [95% CI, 3.9%\u201310.7%]), encephalopathy (6.1% [95% CI, 1.9%\u201312.4%]), and the least prevalent was aortic dissection (1.8% [95% CI, 1.1%\u20132.8%]). Prevalence of in\u2010hospital mortality among patients with hypertensive emergency was 9.9% (95% CI, 1.4%\u201324.6%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Our findings demonstrate a pattern of hypertension\u2010mediated organ damage primarily affecting the brain and heart, substantial cardiovascular renal morbidity and mortality, as well as subsequent hospitalization in patients with hypertensive emergencies presenting to the ED.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.029355","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T11:25:28Z","timestamp":1688815528000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Clinical Outcomes in Hypertensive Emergency: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9672-6628","authenticated-orcid":false,"given":"Tariq Jamal","family":"Siddiqi","sequence":"first","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Shariq","family":"Usman","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-1540","authenticated-orcid":false,"given":"Ahmed Mustafa","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Medicine Jinnah Sindh Medical University Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Sarmad","family":"Javaid","sequence":"additional","affiliation":[{"name":"Department of Medicine Jinnah Sindh Medical University Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymen","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5452-2160","authenticated-orcid":false,"suffix":"III","given":"Donald","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2584-5598","authenticated-orcid":false,"given":"John M.","family":"Flack","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Southern Illinois School of Medicine Springfield IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-8834","authenticated-orcid":false,"given":"Daichi","family":"Shimbo","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3449-0672","authenticated-orcid":false,"given":"Eunhee","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Vagelos College of Physicians and Surgeons, Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1347-729X","authenticated-orcid":false,"given":"Daniel W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-1025","authenticated-orcid":false,"given":"Michael E.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000065"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004511"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199411000-00013"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023397"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2005.11.008"},{"key":"e_1_3_1_7_2","volume-title":"StatPearls","author":"Alley WD","year":"2023","unstructured":"Alley WD, Schick MA, Doerr C. 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