{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:56:12Z","timestamp":1788825372861,"version":"build-2803163510"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,12,5]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">It has been postulated that long QT syndrome (LQTS) can cause fetal loss through putative adverse effects of the channelopathy on placenta and myometrial function. The authors aimed to describe the fetal death rate in a population of pregnant women with long QT syndrome and investigate whether women with more severe phenotype had worse fetal outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The authors retrospectively evaluated fetal outcomes of 64 pregnancies from 23 women with long QT syndrome followed during pregnancy in a tertiary pregnancy and heart disease program. Thirteen of 64 pregnancies (20%) resulted in a fetal loss, 12 miscarriages (19%), and 1 stillbirth (1.6%). Baseline maternal characteristics, including age and use of \u03b2\u2010blockers, did not differ between women who experienced a fetal death or not. Maternal corrected QT interval (QTc) was significantly longer in pregnancies that resulted in fetal death compared with live births (median, 518 ms [interquartile range (IQR), 482\u2010519 ms] versus 479 ms [IQR, 454\u2013496 ms],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Mothers treated with \u03b2\u2010blockers had babies born at term with lower birth weight compared with untreated women (2973\u00b1298\u2009g versus 3470\u00b1338\u2009g,\n              <jats:italic>P<\/jats:italic>\n              =0.002). In addition, the birth weight of babies born at term to treated women with QTc &gt;500 ms was significantly lower compared with women with QTc &lt;500\u2009ms (2783\u00b1283\u2009g versus 3084\u00b1256\u2009g,\n              <jats:italic>P<\/jats:italic>\n              =0.029).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Women with long QT syndrome with more severe phenotypes have a higher incidence of fetal death. Maternal QTc is longer in pregnancies that result in fetal loss, and the birth weight of babies born to patients taking \u03b2\u2010blockers with a QTc &gt;500 ms is lower, suggesting that patients with more marked phenotype may experience worse fetal outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.029407","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T11:26:17Z","timestamp":1701170777000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Assessment of Severity of Long QT Syndrome Phenotype and Risk of Fetal Death"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7200-1606","authenticated-orcid":false,"given":"Lisa","family":"Albertini","sequence":"first","affiliation":[{"name":"Division of Cardiology, Electrophysiology, Toronto General Hospital University Health Network Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-2078","authenticated-orcid":false,"given":"Jordan","family":"Ezekian","sequence":"additional","affiliation":[{"name":"Division of Cardiology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Care","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Electrophysiology, Toronto General Hospital University Health Network Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Silversides","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Toronto Pregnancy and Heart Disease Program and Obstetric Medicine Program, Mount Sinai and Toronto General Hospitals Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Sermer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Mount Sinai Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0242-5208","authenticated-orcid":false,"given":"Michael H.","family":"Gollob","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Electrophysiology, Toronto General Hospital University Health Network Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2513-1627","authenticated-orcid":false,"given":"Danna","family":"Spears","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Electrophysiology, Toronto General Hospital University Health Network Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.08.057"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.07.038"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.01.030"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.658021"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.01.039"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.97.5.451"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.09.004"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.12.022"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135202"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.020917"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12804"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.048"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-03682-z"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7251.1708"},{"key":"e_1_3_2_16_2","first-page":"1","article-title":"Cause of fetal death: data from the fetal death report, 2014","volume":"65","author":"Hoyert DL","year":"2016","unstructured":"Hoyert DL, Gregory EC. 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