{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:31:31Z","timestamp":1793363491910,"version":"4.5.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,12,19]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The purpose of this study was to evaluate the timing of the first cardiac surgery, the number of cardiac surgeries performed, and 30\u2010day postoperative mortality rate for children with severe congenital heart defects (sCHDs) in their first 5\u2009years of life.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">This was a population\u2010based data linkage cohort study linking information from 9 European congenital anomaly registries to vital statistics and hospital databases. Data were extracted for 5693 children with sCHDs born from 1995 to 2004. Subgroup analyses were performed for specific types of sCHD. Children with sCHDs underwent their first surgical intervention at a median age of 3.6 (95% CI, 2.6\u20134.5) weeks. The timing of the first surgery for most subtypes of sCHD was consistent across Europe. In the first 5\u2009years of life, children with hypoplastic left heart underwent the most cardiac surgeries, with a median of 4.4 (95% CI, 3.1\u20135.6). The 30\u2010day postoperative mortality rate in children aged &lt;1\u2009year ranged from 1.1% (95% CI, 0.5%\u20132.1%) for tetralogy of Fallot to 23% (95% CI, 12%\u201337%) for Ebstein anomaly. The 30\u2010day postoperative mortality rate was highest for children undergoing surgery in the first month of life. Overall 5\u2010year survival for sCHD was &lt;90% for all sCHDs, except transposition of the great arteries, tetralogy of Fallot, and coarctation of the aorta.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">There were no major differences among the 9 regions in the timing, 30\u2010day postoperative mortality rate, and number of operations performed for sCHD. Despite an overall good prognosis for most congenital heart defects, some lesions were still associated with substantial postoperative death.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.029871","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T10:39:25Z","timestamp":1702895965000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Timing of Cardiac Surgical Interventions and Postoperative Mortality in Children With Severe Congenital Heart Defects Across Europe: Data From the EUROlinkCAT Study"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7410-8573","authenticated-orcid":false,"given":"Mads","family":"Damkj\u00e6r","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Lillebaelt Hospital University Hospital of Southern Denmark Kolding Denmark"},{"name":"Department of Regional Health 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