{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:55:14Z","timestamp":1790182514745,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Stent thrombosis is a rare but deleterious event. Routine coronary angiography with percutaneous coronary intervention (PCI) is often deferred in the presence of laboratory markers of acute inflammation to prevent complications. The aim of this study was to investigate whether an acute inflammatory state is associated with an increased risk of early stent thrombosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Within a prospective single\u2010center registry, the association between preprocedural acute inflammatory activation, defined as C\u2010reactive protein plasma levels &gt;50\u2009mg\/L or a leukocyte count &gt;12 g\/L, and occurrence of early (\u226430\u2009days) stent thrombosis was evaluated. In total, 11\u2009327 patients underwent PCI and of those, 6880 patients had laboratory results available. 49.6% of the study population received PCI for an acute coronary syndrome and 50.4% for stable ischemic heart disease. In patients with signs of acute inflammatory activation (24.9%), PCI was associated with a significantly increased risk for stent thrombosis (hazard ratio, 2.89;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.00001), independent of age, sex, kidney function, number and type of stents, presence of multivessel disease, choice of P2Y12 inhibitor, and clinical presentation. Elevated laboratory markers of acute inflammation were associated with the occurrence of stent thrombosis in both patients with acute coronary syndrome (hazard ratio, 2.63;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and in patients with stable ischemic heart disease (hazard ratio, 3.57;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">An acute inflammatory state at the time of PCI was associated with a significantly increased risk of early stent thrombosis. Evidence of acute inflammation should result in deferred PCI in elective patients, while future studies are needed for patients with acute coronary syndrome.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.032300","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T11:15:56Z","timestamp":1705058156000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Association of Periprocedural Inflammatory Activation With Increased Risk for Early Coronary Stent Thrombosis"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7792-2837","authenticated-orcid":false,"given":"Konstantin A.","family":"Krychtiuk","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II\u2013Division of Cardiology Medical University of Vienna Vienna Austria"},{"name":"Ludwig Boltzmann Institute for Cardiovascular Research Vienna 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