{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:43:13Z","timestamp":1793256193568,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The objective of this study was to investigate cardiac abnormalities in intensive care unit (ICU) survivors of critical illness and to determine whether temporary acute kidney injury (AKI) is associated with more pronounced findings on cardiovascular magnetic resonance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              There were 2175 patients treated in the ICU (from 2015 until 2021) due to critical illness who were screened for study eligibility. Post\u2010ICU patients without known cardiac disease were prospectively recruited from March 2021 to May 2022. Participants underwent cardiovascular magnetic resonance including assessment of cardiac function, myocardial edema, late gadolinium enhancement, and mapping including extracellular volume fraction. Student\n              <jats:italic>t<\/jats:italic>\n              test, Mann\u2010Whitney\n              <jats:italic>U<\/jats:italic>\n              test, and \u03c7\n              <jats:sup>2<\/jats:sup>\n              tests were used. There were 48 ICU survivors (46\u00b115\u2009years of age, 28 men, 29 with AKI and continuous kidney replacement therapy, and 19 without AKI) and 20 healthy controls who were included. ICU survivors had elevated markers of myocardial fibrosis (T1: 995\u00b131\u2009ms versus 957\u00b121\u2009ms,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; extracellular volume fraction: 24.9\u00b12.5% versus 22.8\u00b11.2%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; late gadolinium enhancement: 1% [0%\u20133%] versus 0% [0%\u20130%],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), more frequent focal late gadolinium enhancement lesions (21% versus 0%,\n              <jats:italic>P<\/jats:italic>\n              =0.03), and an impaired left ventricular function (eg, ejection fraction: 57\u00b16% versus 60\u00b15%,\n              <jats:italic>P<\/jats:italic>\n              =0.03; systolic longitudinal strain: 20.3\u00b13.7% versus 23.1\u00b13.5%,\n              <jats:italic>P<\/jats:italic>\n              =0.004) compared with healthy controls. ICU survivors with AKI had higher myocardial T1 (1002\u00b133\u2009ms versus 983\u00b121\u2009ms;\n              <jats:italic>P<\/jats:italic>\n              =0.046) and extracellular volume fraction values (25.6\u00b12.6% versus 23.9\u00b11.9%;\n              <jats:italic>P<\/jats:italic>\n              =0.02) compared with participants without AKI.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">ICU survivors of critical illness without previously diagnosed cardiac disease had distinct abnormalities on cardiovascular magnetic resonance including signs of myocardial fibrosis and systolic dysfunction. Findings were more abnormal in participants who experienced AKI with necessity of continuous kidney replacement therapy during their ICU stay.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT 05034588.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.029492","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T10:56:21Z","timestamp":1682765781000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Cardiovascular Magnetic Resonance in Survivors of Critical Illness: Cardiac Abnormalities Are Associated With Acute Kidney Injury"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-6166","authenticated-orcid":false,"given":"Alexander","family":"Isaak","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Bonn Bonn Germany"},{"name":"Quantitative Imaging Lab Bonn (QILaB) University Hospital Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2840-6136","authenticated-orcid":false,"given":"Isabel","family":"Pomareda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-3965","authenticated-orcid":false,"given":"Narine","family":"Mesropyan","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional 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