{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:36:10Z","timestamp":1787880970272,"version":"build-2784847793"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,10,17]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Digoxin prescription in patients with single\u2010ventricle physiology after stage 1 palliation is associated with reduced interstage death. Prior literature has primarily included patients having undergone the Norwood procedure. We sought to determine if digoxin prescription at discharge in infants following hybrid stage 1 palliation was associated with improved transplant\u2010free interstage survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A retrospective multicenter cohort analysis was conducted using data from the National Pediatric Cardiology Quality Improvement Collaborative registry data from 2008 to 2021. Infants with functional single ventricles and aortic arch obstruction discharged home after the hybrid stage 1 palliation hospitalization were included. Patients were excluded if they had supraventricular tachycardia or conversion to Norwood operation. The primary outcome was transplant\u2010free survival. Multivariable logistic regression analysis including a propensity score for digoxin use identified associations between digoxin use and interstage death or transplant. Of 259 included infants from 45 sites, 158 (61%) had hypoplastic left heart syndrome. Forty\u2010nine percent had a gestational age \u226438\u2009weeks, 18% had a birth weight &lt;2.5 kg, and 58% had a preoperative risk factor. Of the 259 subjects, 129 (50%) were discharged on digoxin. Interstage death or transplant occurred in 30 (23%) patients in the no\u2010digoxin group compared with 18 (14%) in the digoxin group (\n                      <jats:italic>P<\/jats:italic>\n                      =0.06). With multivariate analysis, discharge digoxin prescription was associated with a lower risk of interstage death or transplant (adjusted odds ratio, 0.48 [95% CI, 0.24\u20130.93];\n                      <jats:italic>P<\/jats:italic>\n                      =0.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In infants with single\u2010ventricle physiology who underwent hybrid stage 1 palliation, digoxin prescription at hospital discharge was associated with improved interstage transplant\u2010free survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.029521","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T07:47:56Z","timestamp":1696664876000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Association of Digoxin Use With Transplant\u2010Free Interstage Survival in Infants Palliated With a Stage 1 Hybrid Procedure"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7358-1772","authenticated-orcid":false,"given":"Reshma K.","family":"Reddy","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Shawn Jenkins Children\u2019s Hospital, Medical University of South Carolina Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinai C.","family":"Zyblewski","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Shawn Jenkins Children\u2019s Hospital, Medical University of South Carolina Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7685-7877","authenticated-orcid":false,"given":"Shahryar M.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Shawn Jenkins Children\u2019s Hospital, Medical University of South Carolina Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Godown","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Monroe Carell Jr. Children\u2019s Hospital, Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Bradley","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiothoracic Surgery, Department of Surgery, Shawn Jenkins Children\u2019s Hospital Medical University of South Carolina Shawn Jenkins Children\u2019s Hospital Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8406-5957","authenticated-orcid":false,"given":"David W.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children\u2019s Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4069-1443","authenticated-orcid":false,"given":"Rachel K.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Monroe Carell Jr. Children\u2019s Hospital, Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2246-4215","authenticated-orcid":false,"given":"Tyler N.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2844-7520","authenticated-orcid":false,"given":"Katherine E.","family":"Bates","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics C.S. Mott Children\u2019s Hospital, University of Michigan Medical School Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9053-741X","authenticated-orcid":false,"given":"L. LuAnn","family":"Minich","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Primary Children\u2019s Hospital University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7713-0258","authenticated-orcid":false,"given":"John M.","family":"Costello","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Shawn Jenkins Children\u2019s Hospital, Medical University of South Carolina Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002376"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.04.028"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.05.020"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951118000926"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002566"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-1884-x"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2021.08.082"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951118000999"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-021-02543-y"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2020.101299"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-016-1450-3"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2021.12.040"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.06.071"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2019.06.061"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.08.020"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.05.048"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-021-02621-1"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-014-0974-7"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021443"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12020"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2011.00536.x"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.029521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:43:49Z","timestamp":1715589829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.029521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":22,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2023,10,17]]}},"alternative-id":["10.1161\/JAHA.123.029521"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.029521","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,17]]},"assertion":[{"value":"2023-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e029521"}}