{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:58:46Z","timestamp":1779263926498,"version":"3.51.4"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,11,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">HIV infection and abacavir\u2010containing antiretroviral regimens are associated with vascular endothelial dysfunction and increased cardiovascular risk. Positron emission tomography (PET)\u2010derived myocardial blood flow reserve (MBFR), the ratio of vasodilator stress to rest myocardial blood flow, is a well\u2010validated measure of coronary microvascular health and marker of cardiovascular risk. Our objective was to compare MBFR among people with HIV (PWH) with matched non\u2010HIV controls and to assess whether switching from dolutegravir\/lamivudine\/abacavir to the non\u2010abacavir regimen bictegravir\/emtricitabine\/tenofovir alafenamide (TAF) would improve MBFR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Thirty\u2010seven PWH were 1:2 matched on cardiovascular risk factors to 75 people without HIV, and MBFR corrected for differences in resting hemodynamics was compared in a cross\u2010sectional design. PWH were majority men (68%) with a mean age of 56\u2009years. Mean stress myocardial blood flow (1.83\u2009mL\/min per g [95% CI, 1.68\u20131.98] versus 2.40\u2009mL\/min per g [95% CI, 2.25\u20132.54];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and MBFR (2.18 [95% CI, 1.96\u20132.40] versus 2.68 [95% CI, 2.47\u20132.89];\n              <jats:italic>P<\/jats:italic>\n              =0.002) was significantly lower in PWH than in people without HIV. In a single\u2010arm, multicenter trial, a subset of 25 PWH who were virologically suppressed on dolutegravir\/lamivudine\/abacavir underwent positron emission tomography myocardial perfusion imaging at baseline and after switching to bictegravir\/emtricitabine\/TAF. MBFR was unchanged after switching to bictegravir\/emtricitabine\/TAF for a mean of 27\u2009weeks (MBFR, 2.34 to 2.29;\n              <jats:italic>P<\/jats:italic>\n              =0.61), except in PWH with impaired MBFR at baseline (&lt;2.00; N=6) in whom MBFR increased from 1.58 to 2.02 (\n              <jats:italic>P<\/jats:italic>\n              =0.02).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">PWH had reduced coronary microvascular function compared with controls without HIV. Coronary microvascular function did not improve after switching from dolutegravir\/lamivudine\/abacavir to bictegravir\/emtricitabine\/TAF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; unique identifier: NCT03656783.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.029541","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T10:14:28Z","timestamp":1699611268000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Coronary Microcirculatory Dysfunction in People With HIV and Its Association With Antiretroviral Therapy"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4221-8078","authenticated-orcid":false,"given":"Daniel M.","family":"Huck","sequence":"first","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-2091","authenticated-orcid":false,"given":"Brittany","family":"Weber","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7893-8136","authenticated-orcid":false,"given":"Sean","family":"Parks","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0598-6502","authenticated-orcid":false,"given":"Sanjay","family":"Divakaran","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6647-639X","authenticated-orcid":false,"given":"Jenifer M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney F.","family":"Bibbo","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0667-8720","authenticated-orcid":false,"given":"Leanne","family":"Barrett","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0572-912X","authenticated-orcid":false,"given":"Jon","family":"Hainer","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA 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A.","family":"Triant","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Massachusetts General Hospital Harvard Medical School Boston MA USA"},{"name":"Division of General Internal Medicine Massachusetts General Hospital, Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Massachusetts General Hospital Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4913-0442","authenticated-orcid":false,"given":"Nina H.","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Boston Medical Center Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Melbourne","sequence":"additional","affiliation":[{"name":"HIV Medical Affairs, Gilead Sciences, Inc. 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